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本文制备了一种同双链DNA(dsDNA)反应的鼠单克隆抗体(HB_2),这种抗体对多聚dG dC多核苷酸具有特异性,对未变性染色体显示了R带。本文就染色过程提供一些补充资料,并讨论其R带的生化基础。所采用的单克隆HB_2抗体是以非A型非
In this paper, a murine monoclonal antibody (HB2) that reacts with double stranded DNA (dsDNA) was prepared. This antibody is specific for the poly dG dC polynucleotide and shows an R band for the undenatured chromosome. This article provides some additional information on the dyeing process and discusses the biochemical basis of its R band. The monoclonal HB 2 antibody used is non-A-type