白三烯D_4是过敏性慢反应物质的重要组成部分,后者由肥大细胞释放,具有收缩平滑肌、增进血管通透性和促进外分泌活动的作用。作者等研究了白三烯D_4在变应性鼻炎中的作用,并与抗原和组胺进行了比较。患者为对屋内尘土敏感,鼻腔特异性激发试验阳性的成年变应性鼻炎病人。用白三烯D_4、组胺和抗原进行纸片法鼻内激发试验,以空白纸片作对照。以喷嚏数、鼻分泌物量及通气阻力作观察标准。当用阈值剂量激发时,抗原和组胺均引起喷嚏发作,而白三烯D_4和对照不引起喷嚏;鼻 Leukotriene D_4 is an important part of anaphylactic and slow-response substances, which are released by mast cells and have the function of contracting smooth muscle, promoting vascular permeability and promoting exocrine activity. The authors studied the role of leukotriene D_4 in allergic rhinitis and compared it with antigen and histamine. Patients were allergic to rhinitis in the house and allergic rhinitis patients who had positive nasal-specific test. With leukotriene D_4, histamine and antigen disc method nasal challenge test to blank paper as a control. To sneeze the number of nasal secretions and ventilation resistance as the observation criteria. Antigen and histamine both caused a sneeze attack when challenged with a threshold dose, whereas leukotriene D_4 and controls did not cause sneezing; nasal