论文部分内容阅读
Objective:To investigate the relationship between single nucleotide polymorphisms (SNP) in murine double minute 2 (MDM2) and susceptibility and biological behavior of hepatocellular carcinoma (HCC). Methods: MDM2 (rs2279744 site) polymorphism in peripheral blood from 166 patients with HCC and 157 healthy controls were detected by SYBR GREEN PCR method and the relationship between MDM2 polymorphism and susceptibility and biological behavior of HCC was analyzed by comparing the differences of genotypes in two populations. Results:There was no statistical significance between two groups in terms of MDM2 allele distribution in research population (P=0.753). The risk of HCC onset in individuals with GG+TG genotype was 1.698 times of those with TT genotype in case group (95%CI=1.027~2.808). MDM2 SNP was associated with HBV infection and the degree of tumor differentiation (P<0.05). The incidence of alleles in experimental group (T, 0.49; G, 0.51) was very different from that in control group (T, 0.59; G, 0.41) (P=0.015). The incidence of GG genotype in patients with HCC (22.29%) was signiifcantly higher than those without HCC (13.38%). Compared with TT genotype, G allele or GG genotype had more correlation with HCC onset. Conclusion:Compared with TT genotype, MDM2 promoter SNP309 G allele or GG genotype is more associated with HCC onset in Chinese population.