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生理条件下,丘脑下部释放的黄体生成素释放激素(LH-RH)经垂体门静脉转运至腺垂体,促进黄体生成素(LH)及卵泡刺激素(FSH)的合成和分泌,并继而促进性腺的生长和发育,精子的生成,卵泡发育和排卵以及性激素的合成和分泌。LH-RH现已人工合成,并已合成了上千种的LH-RH类似物,畜牧及鱼业用其促进排卵及提高家畜繁殖,医学临床则用于触发排卵及治疗不育。但是,动物实验和临床观察都发现,当外源性注入大剂量的LH-RH或某些LH-RH的高活性类似物(以下简称LH-RH-A)时,相反地对生殖系统具有抑制作用,
Under physiological conditions, LH-RH released from the hypothalamus is transported to the pituitary gland by the pituitary gland to promote the synthesis and secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn promotes gonadal Growth and development, sperm production, follicular development and ovulation, and the synthesis and secretion of sex hormones. LH-RH has been synthesized and has synthesized thousands of LH-RH analogues, livestock and fish industry to promote ovulation and improve livestock breeding, clinical medicine is used to trigger ovulation and treatment of infertility. However, both animal experiments and clinical observations have found that concomitantly inhibiting reproduction when exogenously injected with high doses of LH-RH or some highly active analogue of LH-RH (hereinafter referred to as LH-RH-A) effect,