自体骨髓移植治疗白血病的缺点是复发率高 ,复发主要是回输的自体骨髓中含有残留的微量白血病细胞。在回输前进行骨髓净化具有降低复发率的作用。对自体骨髓在回输前进行体外净化是当前自体骨髓移植研究的主要课题之一。现就近年来骨髓净化的研究综述如下。1　反义核苷酸净化法 The disadvantage of autologous bone marrow transplantation for the treatment of leukemia is that the recurrence rate is high. The recurrence is mainly caused by the residual micro leukemia cells in the infused autologous bone marrow. Bone marrow purification before reinfusion has the effect of reducing the recurrence rate. Purification of autologous bone marrow in vitro prior to transfusion is one of the major topics in current autologous bone marrow transplantation studies. The following is a summary of studies on bone marrow purification in recent years. 1 antisense nucleotide purification method