据近期出版的《自然》杂志报道,B-RAF 蛋白作为分子标记在多种肿瘤的发生发展中充当着重要角色。已知多数突变是通过促进其催化活性而发挥作用,但近年来的研究提示,即使这些催化活性被削弱,它也能导致肿瘤发生。以往研究认为,信号传导路径的持续开启将导致细胞过度增殖,从而引发肿瘤生成,其中 RAS、 According to recently published “Nature” magazine, B-RAF protein as a molecular marker plays an important role in the development of a variety of tumors. Most mutations are known to act by promoting their catalytic activity, but recent studies suggest that even though these catalytic activities are impaired, it can cause tumors to develop. Previous studies suggest that the continued opening of signal transduction pathways will lead to over-proliferation of cells, thus triggering tumorigenesis, in which RAS,