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目的:比较阿奇霉素与头孢呋辛治疗儿童呼吸道感染的疗效及对患儿血清前白蛋白(PA)、C反应蛋白(CRP)与降钙素原(PCT)水平的影响。方法:120例呼吸道感染患儿随机分为两组各60例。观察组采用阿奇霉素(10 mg·kg~(~(-1))·d~(-1)ivd)治疗,对照组采用头孢呋辛钠(30 mg·kg~(-1),ivd,q8h)治疗,疗程均为5d。比较两组患儿治疗前后CRP、PA、PCT水平变化,以及临床症状消失时间和疗效。结果:治疗后,两组患儿的CRP和PCT均明显降低,PA明显升高(P<0.05),但组间差异无统计学意义(P>0.05)。观察组患儿咳嗽消失、退热、肺啰音消失和气急消失时间均明显短于对照组(P<0.05)。两组疗效和药品不良反应发生率差异无统计学意义(P>0.05)。结论:阿奇霉素治疗儿童呼吸道感染的疗效与头孢呋辛钠相当,但症状消失较快。
Objective: To compare the curative effect of azithromycin and cefuroxime on children respiratory tract infection and their influence on serum prealbumin (PA), C-reactive protein (CRP) and procalcitonin (PCT). Methods: 120 children with respiratory tract infection were randomly divided into two groups of 60 cases. The observation group was treated with azithromycin (10 mg · kg -1 · d -1 ivd), while the control group was treated with cefuroxime sodium (30 mg · kg -1, iv d, q 8 h) Treatment, treatment are 5d. The changes of CRP, PA, PCT levels before and after treatment in both groups were compared, and the disappearance time and efficacy of clinical symptoms were compared. Results: After treatment, CRP and PCT in both groups were significantly decreased, PA was significantly increased (P <0.05), but there was no significant difference between the two groups (P> 0.05). The cough disappeared, fever, disappearance of pulmonary rales and disappearance of shortness of breath in observation group were significantly shorter than those in control group (P <0.05). There was no significant difference in the incidence of adverse reactions and adverse reactions between the two groups (P> 0.05). Conclusion: The efficacy of azithromycin in treating childhood respiratory infection is comparable to that of cefuroxime sodium, but the symptoms disappear rapidly.