对胃癌扩大根治术应否合并脾脏切除,分歧很大,争论之焦点为胃癌患者的脾脏究竟起正性抑或负性免疫作用。资料表明脾脏在预防肿瘤发生或在肿瘤形成的初始阶段,发挥正性免疫作用;一旦胃癌发展至中、晚期,脾脏的正性免疫功能渐趋削弱,甚至表现出以抑制为主的负性免疫功能。 Whether or not the extended radical gastrectomy for gastric cancer should be combined with splenectomy is quite different. The focus of debate is whether the spleen of gastric cancer patients has positive or negative immune function. The data show that the spleen plays a positive immune role in the prevention of tumorigenesis or in the initial stage of tumor formation; once the gastric cancer develops to the middle and late stages, the positive immune function of the spleen weakens gradually, and even shows inhibition-based negative immunity. Features.