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目的 探讨低分子肝素 (L MWH)的溶栓作用。方法 用底物显色法和ELISA法测定肾病综合征 (NS)患者应用 LMWH前后血浆组织型纤溶酶原激活剂 (t- PA)与 D-二聚体 (D- D)的水平。结果 皮下注射 LMWH组血浆 t- PA与 D- D水平明显增高 ,而静脉滴注 LMWH组血浆 t- PA与 D- D水平无明显变化。结论 皮下注射 L MWH有明显溶栓作用。
Objective To investigate the thrombolytic effect of low molecular weight heparin (L MWH). Methods The levels of plasma tissue plasminogen activator (t-PA) and D-dimer (D-D) in patients with nephrotic syndrome (NS) before and after LMWH were measured by substrate chromogenic assay and ELISA. Results The levels of plasma t-PA and D-D in the subcutaneous injection of LMWH were significantly higher than those in the subcutaneous injection of LMWH. There was no significant difference in the levels of plasma t-PA and D-D in the subcutaneous injection of LMWH. Conclusion Subcutaneous injection of L MWH has obvious thrombolytic effect.