恶性肿瘤侵袭及转移的机制研究已进入分子生物学的水平,细胞外基质(ECM)和血管基底膜的降解是恶性肿瘤浸润和转移的关键环节。研究表明,肿瘤细胞侵袭转移能力的强弱与其诱导产生的蛋白酶降解ECM及基底膜的能力密切相关,而基质金属蛋白酶(MMPs)则是其中最重要的一组蛋白酶,在肿瘤的侵袭和转移中起着重要的作用。RECK基因是一种新型基质金属蛋白酶抑制剂,可在转录后水平抑制多种MMPs的表达,进而有效地抑制肿瘤的侵袭与转移。 Mechanism of invasion and metastasis of malignant tumor has entered the level of molecular biology, the degradation of extracellular matrix (ECM) and vascular basement membrane is a key link in the invasion and metastasis of malignant tumor. Studies have shown that the invasion and metastasis of tumor cells is closely related to their ability to induce degradation of ECM and basement membrane by proteases. Matrix metalloproteinases (MMPs) are the most important group of proteases in the invasion and metastasis of tumors It plays an important role. RECK gene is a new type of matrix metalloproteinase inhibitor, which can inhibit the expression of multiple MMPs at the post-transcriptional level, thereby effectively inhibiting tumor invasion and metastasis.