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以泊洛沙姆188(P188)为稳定剂,采用溶剂置换法制备眼用氟比洛芬聚ε-己内酯纳米粒(FB-PεCL-NPs)。通过冻融试验和冻干显微镜考察和优化预冻和第一次干燥(PD)参数;采用试验设计确定第二次干燥(SD)参数和组分(稳定剂和保护剂)浓度。依据所期望的理化性质筛选优化处方。优化结果为:以3.5%P188为稳定剂,8%聚乙二醇为保护剂,在+10℃预冻1 h,
The flurbiprofen poly (ε-caprolactone) nanoparticles (FB-PεCL-NPs) were prepared by solvent replacement method using poloxamer 188 (P188) as stabilizer. Freeze-thaw and freeze-dried microscopy were used to examine and optimize the pre-freeze and first-pass drying (PD) parameters; the second dry (SD) parameters and components (stabilizer and protectant) concentrations were determined using a trial design. According to the desired physical and chemical properties screening optimization prescription. The optimized results were as follows: 3.5% P188 as stabilizer, 8% polyethylene glycol as protective agent, pre-freezing at + 10 ℃ for 1 h,