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中华急诊医学会已将纳络酮列为心肺复苏治疗药物.现将其在新生儿危重症抢救中的临床应用问题简述如下.1 纳络酮的药物动力学及药理机制纳络酮又称丙烯吗啡酮,易溶于水,呈酸性,静脉、皮下、肌注、气管内给药均可.其中以静脉和气管内给药起效快,1～3分钟即产生效应.透过血脑屏障的速度为吗啡的12倍,主要经肝脏代谢,与葡萄糖醛酸结合后经尿排出.纳络酮为阿片受体竞争性药物,与阿片受体有很强的亲和力,可与脑干等部位的阿片受体结合竞争性地阻断内源性阿片样物质(ols)所介导的各种效应.纳络酮能增加应激机体的心
Chinese Association of Emergency Medicine Naloxone has been listed as cardiopulmonary resuscitation drugs now its clinical application in the rescue of critically ill neonatal problems are summarized as follows.1 Naloxone pharmacokinetics and pharmacological mechanisms Naloxone, also known as Propofol, easily soluble in water, acidic, intravenous, subcutaneous, intramuscular, intratracheal administration can be. Among them intravenous and intratracheal administration of rapid onset, 1 to 3 minutes to produce the effect through the blood brain Barrier speed is 12 times that of morphine, mainly by the liver metabolism, combined with glucuronic acid excreted through the urine.Naloxone is a opioid receptor competing drugs, and opioid receptors have a strong affinity with the brain stem, etc. The opioid receptor binding site competitively blocks various effects mediated by endogenous opioids (ols). Naloxone increases the stress-induced heart