论文部分内容阅读
目的探讨血清胱抑素C(Cys C)与IgA肾病Lee氏病理分级的相关性。方法根据Lee氏病理分级标准,244例IgA肾病患者(A组)分为轻度损害组(A1组,108例)、中度损害组(A2组,102例)、重度损害组(A3组,34例);另选取30例健康体检者为对照组(B组)。采用颗粒增强透射免疫比浊法、肌氨酸氧化酶法和尿素酶法分别检测血清Cys C、血清肌酐(SCr)和血尿素氮(BUN)水平,采用慢性肾脏病流行病学合作研究公式(CKD-EPI)估算肾小球滤过率(eGFR)。结果与B组相比,A组以及A2、A3组血清Cys C、BUN、SCr水平升高,eGFR降低(P<0.01)。随着肾脏病变程度加重,血清Cys C、BUN、SCr水平逐渐升高,而eGFR逐渐降低(P<0.05或P<0.01)。IgA肾病Lee氏病理分级与血清Cys C、BUN、SCr呈正相关(r=0.456、0.429、0.454,P<0.01),与eGFR呈负相关(r=-0.331,P<0.01)。A1、A2、A3组血清Cys C的阳性检出率高于BUN和SCr(P<0.05)。结论 Cys C可能是反映IgA肾病早期病变程度的敏感性指标。
Objective To investigate the correlation between serum cystatin C (Cys C) and Lee’s histopathological grade of IgA nephropathy. Methods A total of 244 patients with IgA nephropathy (group A) were divided into mild injury group (group A1, n = 108), moderate damage group (group A2, n = 102), severe injury group 34 cases); another 30 healthy people were selected as the control group (group B). Serum levels of Cys C, serum creatinine (SCr) and blood urea nitrogen (BUN) were measured by particle-enhanced immunoassay, sarcosine oxidase and urease assays, respectively, using the formula of epidemiological study of chronic kidney disease CKD-EPI) estimated glomerular filtration rate (eGFR). Results Compared with group B, the levels of serum Cys C, BUN and SCr in group A and groups A2 and A3 were increased and eGFR was decreased (P <0.01). As the degree of renal disease increased, the levels of serum Cys C, BUN and SCr gradually increased, while the eGFR decreased gradually (P <0.05 or P <0.01). IgA nephropathy Lee’s pathological grade and serum Cys C, BUN, SCr was positively correlated (r = 0.456,0.429,0.454, P <0.01), and negative correlation with eGFR (r = -0.331, P <0.01). The positive detection rate of serum Cys C in A1, A2 and A3 groups was higher than that in BUN and SCr (P <0.05). Conclusion Cys C may be a sensitive index to reflect the degree of early lesions of IgA nephropathy.