论文部分内容阅读
金葡菌是许多人类致病原中的一种,20世纪30年代后期由于磺胺药物的应用而有效地控制了金葡菌感染,但因感染部位的脓液及细菌耐药性的形成,使得这类药物对金葡菌的作用大为降低。20世纪40年代初青霉素G的应用,暂时解决了葡萄球菌感染问题,由于青霉素的连续应用而出现了耐药菌株,产生了青霉素酶。1948年耐药菌株大流行,已严重地削弱了青霉素的治疗价值;20世纪50年代末,金葡菌对包括红霉素、链霉素和四环素类在内的几乎所有全身性应用抗生素都产生了耐药性,因此,应用抗生素已无法控制医
Staphylococcus aureus is one of many human pathogenic agents, the late 1930s due to the application of sulfa drugs and effectively control the S. aureus infection, but the infection site of pus and bacterial resistance formation, making The role of such drugs on Staphylococcus aureus greatly reduced. The early 1940s penicillin G application, the temporary solution to the problem of staphylococcal infection, due to the continuous application of penicillin resistant strains, resulting in penicillinase. The drug-resistant strains pandemic in 1948 severely weakened the therapeutic value of penicillin; in the late 1950s, S. aureus produced almost all systemic antibiotics, including erythromycin, streptomycin and tetracyclines Drug resistance, therefore, the use of antibiotics has been unable to control the doctor