根管治疗术诊次间产生疼痛与肿胀等急性症状称诊次间痛(Interappointment Pain,IAP)。其发生率为7.2～50％。学者们指出发生因素为:(1)根管清理不彻底或残留感染;(2)根管清理创伤,器械超出根尖孔或将感染物质推出根尖孔;(3)根管冲洗剂或消毒剂对根尖周组织的刺激性;(4)暂封体过高产生创伤(牙合)。笔者将4例典型病报道如下: Acute symptoms of pain and swelling during endodontic treatment refer to Interappointment Pain (IAP). The incidence of 7.2 to 50%. Scholars pointed out that the factors are as follows: (1) root canal cleaning is not complete or residual infection; (2) root canal to clean the wounds, instruments beyond the apical foramen or infected substances introduced into the apical foramen; (3) root canal irrigant or disinfection Agent on the periapical tissue irritation; (4) Temporary closure is too high to produce trauma (occlusion). The author will be 4 cases of typical disease reported as follows: