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在精子发生过程中出现生精障碍将造成男性不育,而染色体异常是主要因素之一。早在1957年Ferguson-Smith就观察到男性不育患者中有的病人的细胞核边缘有Barr’s小体;1959年Jacobs和Strong报道了首例Klinefelter’s综合症的染色体核型为47,XXY,多一个X性染色体。三十多年来世界上许多学者仍不断地对男性不育患者的染色体异常进行深入的研究,并发现一些常染色体异常也会造成男性不育。我国从八十年代中期起因男性不育专科门诊的开设,极大地推动了国内对男性不育患
Spermatogenesis in the process of spermatogenesis disorders will result in male infertility, and chromosomal abnormalities are one of the main factors. As early as 1957, Ferguson-Smith observed that some patients in male infertility had Barr’s corpus at the nucleus edge. In 1959, Jacobs and Strong reported that the first Klinefelter’s syndrome had a karyotype of 47, XXY and one more X Sex chromosomes. For more than thirty years, many scholars in the world continue to study the chromosomal abnormalities in male patients with infertility, and found that some autosomal abnormalities can cause male infertility. Since the mid-eighties since the establishment of male infertility specialist out-patient, which greatly promoted the domestic male infertility