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目的:观察2型糖尿病中阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的患病情况,临床特点及血清蛋白羰基水平。方法:选择2型糖尿病患者203例,进行多导联睡眠呼吸监测,记录AHI、年龄、身高、体重指数(BMI)、腰围、糖尿病病程,测定空腹血糖、糖化血红蛋白(HbA1c)、血清蛋白羰基(PCO)水平。结果:2型糖尿病患者中OSAHS患病率为79.2%,其中重度30.4%,中度45.4%,轻度24.2%。伴OSAHS患者的BMI、腰围、空腹血糖、HbA1c及血清PCO水平均高于未合并OSAHS者,差别有统计学意义(P<0.01)。回归分析发现HbA1c与OSAHS患病风险呈独立正相关(P<0.05,OR=6.11),HbA1c、BMI、腰围、病程、血清PCO水平均与AHI独立正相关,HbA1c为最主要的独立危险因素(P<0.05)。结论:2型糖尿病患者中OSAHS的患病率较高,合并OSAHS的患者血糖控制差,体内蛋白质氧化损伤加重。
Objective: To observe the prevalence, clinical characteristics and serum carbonyls of obstructive sleep apnea-hypopnea syndrome (OSAHS) in type 2 diabetes. Methods: A total of 203 patients with type 2 diabetes mellitus were selected for monitoring of multi-lead sleep respiration. AHI, age, height, body mass index (BMI), waist circumference and duration of diabetes were recorded. Fasting blood glucose, HbA1c and serum albumin PCO) level. Results: The prevalence of OSAHS in type 2 diabetic patients was 79.2%, of which 30.4% were severe, 45.4% moderate and 24.2% mild. The BMI, waist circumference, fasting blood glucose, HbA1c and serum PCO levels in patients with OSAHS were significantly higher than those without OSAHS (P <0.01). Regression analysis showed that there was a positive correlation between HbA1c and OSAHS (P <0.05, OR = 6.11), HbA1c, BMI, waist circumference, duration of disease and serum PCO levels were independently and independently related to AHI. HbA1c was the most important independent risk factor P <0.05). Conclusion: The prevalence of OSAHS is higher in patients with type 2 diabetes mellitus, and the patients with OSAHS have poor glycemic control and aggravate the protein oxidative damage in vivo.