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目的 观察幽门螺杆菌 (Hp)感染及血清白细胞介素 6 (IL 6 )的浓度与初发脑梗死的关系 ,探讨Hp感染可能导致脑梗死的机制。方法 采用病例对照 1∶1配对的研究方式 ,检测 80例初发脑梗死患者(观察组 )和对照组血清标本的Hp特异性抗体IgG(Hp IgG)、IL 6及C 反应蛋白的浓度。 结果 观察组81% (6 5 / 80 )、对照组 5 8% (46 / 80 )Hp IgG阳性 ,两者比较有显著性差异 (χ2 =10 .31,P <0 .0 1,OR =3.38,95 %CI为 1.6 1～ 7.0 9) ;观察组的Hp IgG、IL 6浓度均明显高于对照组 (均为P <0 .0 1)。Hp IgG浓度与IL 6浓度正相关 (r =0 .6 6 ,P <0 .0 1) ,与C 反应蛋白浓度正相关 (r =0 .5 8,P <0 .0 1) ,与临床神经功能缺损评分正相关 (r =0 .74 ,P <0 .0 1)。结论 Hp感染与初发脑梗死的发生有关 ,脑梗死发病后血清Hp IgG浓度亦升高 ,且随Hp IgG浓度的升高血清IL 6、C 反应蛋白浓度亦相应升高 ,患者的临床神经功能缺损程度也越重。
Objective To investigate the relationship between Helicobacter pylori (Hp) infection, serum interleukin 6 (IL 6) concentration and primary cerebral infarction and to explore the possible mechanism of Hp infection in cerebral infarction. Methods Hp-specific IgG (Hp IgG), IL-6 and C-reactive protein in serum of 80 patients with primary cerebral infarction (observation group) and control group were detected by case-control 1: 1 paired study. Results The positive rate of Hp IgG was 81% (65/80) in the observation group and 58% (46/80) in the control group, with significant difference (χ2 = 10.31, P <0.01, OR = 3.38 , 95% CI 1.6 1 ~ 7.0 9). The concentrations of Hp IgG and IL 6 in the observation group were significantly higher than those in the control group (all P <0.01). Hp IgG concentration was positively correlated with IL 6 concentration (r = 0.666, P <0.01), and positively correlated with C-reactive protein concentration (r = 0.58, P <0.01) Neurological deficit scores were positively correlated (r = 0.74, P <0.01). Conclusions Hp infection is associated with the occurrence of primary cerebral infarction. The serum Hp IgG concentration is also increased after onset of cerebral infarction. The concentration of serum IL-6 and C-reactive protein is also increased with the increase of Hp IgG concentration. The clinical neurological function The extent of the defect is also heavier.