采用薄膜分散-超声法制备蛇床子素非离子表面活性剂囊泡,以包封率为指标通过正交设计优化处方和工艺。并考察了所得优化囊泡的形态、平均粒径和分布、包封率及体外释药行为。结果表明,制品外观呈球形或椭圆形,平均粒径为(246.1±12.3)nm,多分散系数为0.171,包封率为87.4%,体外释药行为符合Higuchi方程(r=0.998 2)。 Osthelrin nonionic surfactant vesicles were prepared by membrane dispersion - ultrasonic method. The encapsulation efficiency was used as an index to optimize the formulation and technology by orthogonal design. The optimized vesicle morphology, average particle size and distribution, entrapment efficiency and in vitro release behavior were investigated. The results showed that the appearance of the product was spherical or oval with an average diameter of (246.1 ± 12.3) nm, a polydispersity coefficient of 0.171 and an entrapment efficiency of 87.4%. The in vitro drug release behavior was consistent with the Higuchi equation (r = 0.998 2).