论文部分内容阅读
本文报告应用双盲法在一组重症病毒性肝炎者中,观察类固醇激素对乙型肝炎病毒标记的影响,以研究其对这类患者免疫反应的作用。16例重症病毒性肝炎者随机分成两组:治疗组8例口服甲基强的松龙(48mg/天),另8例对照组服“安慰剂”。所有患者观察至少4周。除常规肝功能试验外,所有患者服药前后均测定了外周血的乙型肝炎病毒标记,包括:HBsAg(补体结合法)、抗HBs(被动血凝法)、HBcAg(固相放射免疫法)、抗HBc滴度(双抗体放射免疫沉淀法)、Dane颗粒相关的DNA多聚酶活力(Robinson法)、及HBeAg和抗KBe(凝胶扩散法)。
This article reports the use of double-blind method in a group of patients with severe viral hepatitis, observed steroid hormones on hepatitis B virus markers to study its role in this type of immune response. Sixteen patients with severe viral hepatitis were randomized into two groups: 8 in the treatment group were given methylprednisolone (48 mg / day), and the other 8 in the control group were given “placebo”. All patients were observed for at least 4 weeks. In addition to routine liver function tests, all patients were tested for hepatitis B virus markers before and after treatment, including HBsAg (complement fixation), anti-HBs (passive coagulation), HBcAg (solid phase radioimmunoassay) Anti-HBc titers (dual antibody radioimmunoprecipitation), Dane particle-associated DNA polymerase activity (Robinson’s method), and HBeAg and anti-KBe (gel diffusion).