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目的：研究组合硬化剂对家兔胆囊的硬化作用，观察治疗肾囊肿的远期临床疗效。方法：应用四环素与氟美松组合硬化剂注入家兔胆囊，与生理盐水和无水乙醇对比观察其对胆囊壁的作用；与无水乙醇对比观察介入硬化治疗肾囊肿的疗效。组合硬化剂治疗组４１ 例，男２３ 例，女１８ 例，年龄４３ 岁～７２ 岁；无水乙醇对照组４０ 例，男２８ 例，女１２ 例，年龄４５ 岁～７０ 岁。结果：动物实验，生理盐水组胆囊上皮均无组织学异常改变；无水乙醇组胆囊内出血渗液多，吸收慢，纤维组织增生少；组合硬化剂组胆囊内渗液少，吸收快，纤维组织增生明显。临床治疗肾囊肿，组合硬化剂具有刺激囊内渗液量少，囊腔闭合快，治愈率高，无复发的优点３ ，６ ，１２ 个月和３ ，５ 年治愈率分别为５１ ．２ ％ ，９０ ．２ ％ ，９５ ．１ ％ ，１００ ％ ，１００ ％ ；而无水乙醇组分别为７ ．５ ％ ，３７ ．５ ％ ，６５ ．０ ％ ，８７ ．５ ％ ，９０ ．０ ％ ，两组间比较均有显著性差异（ Ｐ＜ ０ ．０５ ，＜ ０ ．０１ ，＜ ０ ．０１ ，＜ ０ ．０５ ，＜ ０ ．０５） 。５ 年观察组合硬化剂组无复发，无水乙醇组１ 例好转，３ 例（７ ．５ ％ ） 复发（ Ｐ＜ ０ ．０５） 。结论：硬化药物组合序贯应用，先?
Objective: To study the sclerosis effect of combined sclerosant on rabbit gallbladder and to observe the long-term clinical curative effect of treating renal cyst. Methods: The tetracycline and dexamethasone combined hardener were injected into the gallbladder of rabbits to observe its effect on the gallbladder wall compared with normal saline and absolute ethanol. The effect of interventional sclerosis on renal cysts was compared with absolute ethanol. Forty-one patients were treated with combined sclerotherapy, including 23 males and 18 females, ranging in age from 43 to 72 years. In the control group, there were 40 males and 28 females, 12 females, aged 45-70 years. Results: There was no histological abnormalities in the gallbladder epithelium in the saline group and in the saline group. The effusion of the gallbladder in the ethanol group was more and slower than that in the saline group, and the fibrosis was less. Hyperplasia obvious. Clinical treatment of renal cysts, combination sclerotherapy has the advantages of less exudate in the capsule, faster closure of the cyst, higher cure rate, and no recurrence. The cure rates at 3, 6, 12 months and 3 and 5 years were 51 and 51 respectively. 2%, 90. 2%, 95. 1%, 100% and 100%, respectively, while the absolute ethanol group was 7 respectively. 5%, 37. 5%, 65. 0%, 87. 5%, 90. 0%. There was significant difference between the two groups (P <0.05, <0.01, <0.01, <0.05, <0.05). In 5 years, there was no recurrence in the combination sclerotherapy group, 1 case improved in the group of absolute ethanol and 3 cases (7.5%) (P <0. 05). Conclusions: The sequential combination of sclerotic drug combinations, first