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目的 :探讨流行性出血热 (EHF)患者的预后与血清丙胺酸转氨酶 (ALT)和草酰乙酸转氨酶 (AST)水平的关系。方法 :2 0 8例EHF患者入院时在测血、尿、粪常规、血清尿素氮 (BUN)、肌酐 (Cr)及电解质的同时检测ALT和AST ,ALT和AST每周复查 1次 ,其他化验根据病情随时复查。结果 :① 5 5 8%的EHF患者伴有ALT异常 ,41 8%的患者伴有AST异常 ,其中 2 9 3 %患者ALT和AST同时异常 (P <0 0 1)。②血清ALT或AST水平 <2 0 0U/L者预后好 ,>5 0 0U/L者预后差 ,两项同时异常者预后差 (P <0 0 1)。结论 :EHF病毒除了对肾脏损害外 ,对心脏及肝脏亦有损害 ,血清ALT和AST水平可作为EHF预后判断的参考指标。
Objective: To investigate the relationship between the prognosis of patients with epidemic hemorrhagic fever (EHF) and serum alanine aminotransferase (ALT) and oxaloacetate aminotransferase (AST) levels. Methods: Two hundred and eight patients with EHF were admitted to hospital. ALT and AST, ALT and AST were measured simultaneously with blood, urine, fecal routine, serum urea nitrogen (BUN), creatinine (Cr) According to the disease at any time review. RESULTS: Fifty-five to eighty percent of EHF patients had ALT abnormalities, and 41.8% of patients had AST abnormalities. Of them, 293 and 27% of patients had ALT and AST abnormalities at the same time (P <0.01). ② Serum ALT or AST levels <200U / L, good prognosis,> 500U / L, poor prognosis, the two simultaneously abnormal prognosis was poor (P <0.01). Conclusion: The EHF virus not only damages the kidneys, but also damages the heart and liver. The levels of serum ALT and AST can be used as reference indexes for the prognosis of EHF.