糖尿病性肾小球硬化症包括两种类型:即弥漫型和结节型,但以前者为多见。两种炎型的基本病理改变为肾小球毛细血管基膜增厚及系膜区基质的增加,除肾小球之外,包曼氏囊及肾小管的基膜亦可增厚,但呈非特异性。发病机理目前尚未完全明瞭,据报道大致有两种理论,一种认为它与胰岛素的缺乏有关,另一种则认为可能是由于某些先天性缺乏所致。两种看法以前一种居多。众所周知,糖尿病患者肾小球毛细血管基膜的厚度是随患者患病的时间而递增的,据观察其增厚的速度要比 Diabetic glomerulosclerosis includes two types: diffuse and nodular, but the former is more common. The basic pathological changes of the two inflammatory types were glomerular capillary basement membrane thickening and mesangial matrix increase, in addition to glomerular, including Mans Bursal and tubular basement membrane can also be thickening, but was Non-specific. The pathogenesis is not yet fully understood. There are roughly two theories reported, one is that it is related to the lack of insulin, and the other is probably due to some congenital lack of. The two kinds of view before a majority. It is well known that the thickness of glomerular capillary basement membrane in patients with diabetes is increasing with the patient’s time, it is observed that the rate of thickening than