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目的:优选复方双金感冒颗粒的提取工艺。方法:采用正交试验设计法,以方中金莲花和一枝蒿的有效成分荭草苷、牡荆苷、一枝蒿酮酸的含量和浸膏得率为综合评分指标,考察乙醇体积分数、提取时间、加醇倍量3个因素对乙醇提取效果的影响;以方中神香草等的有效成分总多糖、迷迭香酸的含量和浸膏得率为综合评分指标,考察煎煮次数、煎煮时间、加水倍量3个因素对水提取效果的影响;均进行验证试验。结果:优选的最优醇提工艺为10倍量70%乙醇提取2次,每次1.5 h;最优水提工艺为10倍量水提取3次,每次1 h。验证试验中醇提工艺和水提工艺平均综合评分分别为95.55、97.89(RSD=1.01%、0.97%,n=3)。结论:优选的提取工艺简单、稳定、可行,可用于复方双金感冒颗粒的提取。
Objective: To optimize the extraction process of Compound Bijin cold particles. Methods: Orthogonal design method was used to study the contents of triterpene, vitexin, and artemisia in the prescriptions of Triticum aestivum and Artemisia annua, Time, plus alcohol times the three factors on the ethanol extraction effect; herbs such as Fangzhong herbs total polysaccharide, rosmarinic acid content and extract yield as a comprehensive score index to examine the number of boiling, fried Cooking time, water three times the amount of water on the extraction of the impact of factors; are verified test. Results: The optimal alcohol extraction process was 10 times the amount of 70% ethanol extraction twice, each 1.5 h; optimal water extraction process was 10 times the amount of water extracted three times, each 1 h. The average comprehensive scores of alcohol extraction and water extraction were 95.55 and 97.89 (RSD = 1.01%, 0.97%, n = 3) respectively. Conclusion: The optimal extraction process is simple, stable and feasible, which can be used for the extraction of compound bingo cold particles.