胰岛素样生长因子(IGF-1)是循环多肽。曾有报道 IGF-1对脂肪代谢和肝脏生糖作用与胰岛素明显不同,而外周血糖摄取和蛋白质代谢的作用与胰岛素相同。为了阐明 IGF-1细胞内代谢途径和降糖作用涉及的组织,同时测定IGF-1对胰岛素耐受糖尿病大鼠的代谢效应,作者选择雄性80～100g Insulin-like growth factor (IGF-1) is a circulating polypeptide. It has been reported that IGF-1 has markedly different effects on fat metabolism and hepatic gluconeogenesis from insulin, whereas peripheral blood glucose uptake and protein metabolism have the same effect as insulin. In order to elucidate the tissue involved in the metabolic pathway and hypoglycemic activity in IGF-1 cells and to determine the metabolic effects of IGF-1 on insulin-resistant diabetic rats, we selected males (80-100 g)