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以左心室压峰值、左心室舒张末期压、左心室压最大上升速率和下降速率、心输出量、心功等指标衡量左心功能,观察麻醉家兔经股动脉放血导致血容量急剧减少、股动脉平均压降至40mmHg附近并维持20分钟时,静脉输入异紫堇定对左心功能的影响。实验结果表明异紫堇定能全面地改善急性失血动物的左心功能并明显地延长其存活时间。
Left ventricular function was measured by peak values of left ventricular pressure, left ventricular end-diastolic pressure, maximum rate of rise and fall of left ventricular pressure, cardiac output, and cardiac effort. The blood volume was reduced and the blood pressure was decreased in anesthetized rabbits. When the mean arterial pressure dropped to around 40 mmHg and maintained for 20 minutes, the effect of isoprenaline on the left heart function was entered intravenously. The experimental results show that iridonidine can improve the left heart function of acute blood loss animals and significantly prolong the survival time.