多系统器官衰竭(MSOF)常常与严重的败血症相关联,并成为在监护病房中导致病人死亡的重要原因。在败血症发生时,由于胃肠道对氧代谢需要过度增加,会引起肠粘膜的相对性缺血和继之而来的肠粘膜机能障碍;而再通过肠道细菌易位和细菌产物进入体循环而导致败血症加重。作者曾已证实大鼠在发生大肠杆菌菌血症时,小肠微循环有血管收缩和低灌注现象出现。因此,当发生败血症时所有旨在改善微循环血流和组织氧合作用的努力都将为更加有效地预防和治疗MSOF。己酮可可碱 Multiple system organ failure (MSOF) is often associated with severe sepsis and is a significant cause of death in an intensive care unit. In the event of sepsis, the gastrointestinal oxygen metabolism due to the need to increase too much, will cause the relative ischemia of the intestinal mucosa and subsequent intestinal mucosal dysfunction; and then through intestinal bacterial translocation and bacterial products into the systemic circulation and Cause increased sepsis. The authors have confirmed that in rats with E. coli bacteremia, there is vasoconstriction and hypoperfusion in the intestinal microcirculation. Therefore, all efforts aimed at improving microcirculation and tissue oxygenation in the event of sepsis will be to prevent and treat MSOF more effectively. Pentoxifylline