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目的总结106例肺癌支气管动脉内灌注化疗加栓塞(BAI+BAE)的临床效果。方法回顾性分析108例肺癌经支气管动脉共338次介入治疗的疗效,其中单纯支气管动脉灌注化疗66例(共化疗236次);化疗合并栓塞42例(共治疗102次)。两次治疗间隔4～5周。结果66例接受单纯支气管动脉灌注化疗,其中完全缓解(CR)8例,部分缓解(PR)24例,缓解率达45.5%,稳定(SD)26例,进展(PD)8例;有效缓解率45.5%,1年及2年生存率分别为56.1%和36.3%,生存质量明显改善,接受化疗栓塞(BACE)的42例患者中,其中CR 7例,PR 23例,SD 9例,PD 3例,缓解率达71.4%。1年及2年生存率分别为78.5%和62.3%,化疗合并栓塞的疗效优于单纯化疗。结论经支气管动脉灌注化疗或合并用栓塞是安全、有效、易于操作的治疗肺癌的方法。
Objective To summarize the clinical results of 106 cases of bronchial artery infusion chemotherapy combined with embolization (BAI + BAE) in lung cancer. Methods A retrospective analysis of 108 cases of bronchial artery of bronchial artery with a total of 338 interventions, including 66 cases of simple bronchial artery infusion chemotherapy (total of 236 times); chemotherapy combined with embolization in 42 cases (a total of 102 times). Two treatment interval of 4 to 5 weeks. Results Sixty-six patients underwent bronchial artery infusion chemotherapy. Among them, 8 patients were completely relieved (CR), 24 patients were partially relieved (PR), the response rate was 45.5%, 26 patients were stable (SD) and 8 patients were PD. The effective response rate 45.5%, 1-year and 2-year survival rates were 56.1% and 36.3%, respectively. The quality of life was significantly improved. Of the 42 patients who underwent chemoembolization (BACE), 7 were CR, 23 were PR, 9 were SD, For example, the response rate was 71.4%. The 1-year and 2-year survival rates were 78.5% and 62.3%, respectively. Chemotherapy combined with embolization was superior to chemotherapy alone. Conclusions Transbronchial arterial infusion chemotherapy or combined embolization is a safe, effective and easy-to-operate method for the treatment of lung cancer.