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[目的]观察不同剂量的阿托伐他汀对老年人高脂血症的疗效和安全性。[方法]收集符合要求的高脂血症老年人153例,随机分为阿托伐他汀低剂量组(10 mg/d,A组)79例和常规剂量(20 mg/d,B组)74例。分别在治疗前及治疗后第2、8周采集空腹静脉血,比较两组间治疗前后血脂的差异、疗效,并观察肝、肾、肌肉的不良反应。[结果]治疗8周后,A、B组总胆固醇分别下降19.6%、20.0%,低密度脂蛋白胆固醇分别下降17.4%、20.1%,治疗前后差异均有统计学意义(P均<0.01);两组间血脂水平差异无统计学意义(P>0.05)。A、B组治疗后均未发现肝、肾、肌肉的不良反应,差异无统计学意义(P>0.05)。A组治疗后尿酸水平较治疗前下降,差异有统计学意义(P<0.01);两组间治疗后不良反应总体差异无统计学意义(P>0.05)。[结论]口服阿托伐他汀10 mg/d与20 mg/d同样可使老年人血总胆固醇及低密度脂蛋白胆固醇下降。与20 mg/d阿托伐他汀相比,10 mg/d口服无明显肝、肾、肌肉不良反应。10 mg/d组在降脂同时还能降低血尿酸水平,对老年人的降脂治疗是安全、有效的。
[Objective] To observe the efficacy and safety of different doses of atorvastatin on elderly patients with hyperlipidemia. [Methods] A total of 153 elderly patients with hyperlipidemia were enrolled and randomly divided into atorvastatin low dose group (79 mg / d, A group) and conventional dose (20 mg / d, group B) example. Fasting venous blood was collected before treatment and 2 and 8 weeks after treatment respectively. The difference of blood lipid between the two groups was compared before and after treatment. The adverse reactions of liver, kidney and muscle were observed. [Results] After 8 weeks of treatment, the total cholesterol in group A and group B decreased by 19.6% and 20.0%, while the low density lipoprotein cholesterol decreased by 17.4% and 20.1% respectively. The difference was statistically significant before and after treatment (all P <0.01). There was no significant difference in serum lipids between the two groups (P> 0.05). No adverse reactions of liver, kidney and muscle were found in group A and group B after treatment, the difference was not statistically significant (P> 0.05). The level of uric acid in group A was lower than that before treatment (P <0.01). There was no significant difference in adverse reactions between the two groups after treatment (P> 0.05). [Conclusion] Oral administration of atorvastatin 10 mg / d and 20 mg / d can also lower blood total cholesterol and low density lipoprotein cholesterol in the elderly. Compared with 20 mg / d of atorvastatin, 10 mg / d orally had no obvious liver, kidney and muscle adverse reactions. The 10 mg / d group also reduced blood uric acid level while lowering lipid, which was safe and effective for lipid-lowering treatment in the elderly.