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肝母细胞癌35例，应用免疫荧光──流式细胞技术和免疫组化技术分别对肝母细胞瘤P5基因蛋白及增殖细胞核抗原（PCNA）表达进行检测。结果显示：P53、PCNA在肝母细胞瘤的阳性率分别为54．3％、60％，与正常对照肝组织且有显著性差异，而且各组织学类型与正常组均有显著的差异，尤以未分化型明显。并且发现P53与PCNA表达之间存在着一种正相关关系，都与肿瘤的预后等因素有关。
Thirty-five patients with hepatocellular carcinoma were examined for the expression of P5 gene protein and proliferating cell nuclear antigen (PCNA) in hepatoblastoma by immunofluorescence-flow cytometry and immunohistochemistry. The results showed that the positive rates of P53 and PCNA in hepatoblastoma were 54.3% and 60%, respectively, and there was a significant difference from the normal control liver tissue, and there was a significant difference between each histological type and normal group. Obviously undifferentiated. And there is a positive correlation between P53 and PCNA expression, both of which are related to the prognosis of the tumor and other factors.