imatinib相关论文
多学科诊疗手段有利于胃肠道间质瘤的治疗.然而,药师很少被纳入胃肠间质瘤的多学科诊疗团队中.本回顾性研究旨在评估药师在胃肠道......
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Conversion Therapy with Imatinib for Multiple Initially Unresectable Gastrointestinal Stromal Tumors
Objective Multiple primary gastrointestinal stromal tumors(GISTs)of the ileum are rare.As for locally advanced but resec......
Multidrug resistant recurrent/metastatic intestinal GIST expressing KIT exon 9/17 mutation benefited
Objectives We present here a 60-year-old man with recurrent/metastatic intestinal GIST expressing KIT exon 9/17 mutation......
Objective Gastrointestinal stromal tumors(GISTs)represent the most common form of mesenchymal neoplasms in the gastroint......
Pregnancy with metastatic gastrointestinal stromal tumor on imatinib therapy:a case report and liter
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Objective: To investigate the clinicopathological features and prognosis of patients with duodenal stromal tumor after s......
Local recurrence of a large gastric GIST despite adequate resection and adjuvant imatinib mesylate t
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Forty-two compounds(series 8,9 and 10)incorporated with diacylated piperazine have been synthesized and evaluated as nov......
目的 分析伴有t(5；12)/ETV6-PDGFRβ异常髓系肿瘤的临床和实验室特点。方法 采用骨髓细胞短期培养法制备染色体标本,R显带技术进行......
目的 报道一例罕见的同时伴有t(9；22)(q34；q11)和t(15；17)(q24；q21)变异型易位t(5；17)(q32；q21)异常核型的CML慢性期病例,并探讨其与典型......
Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract.Oncogenic KIT or PDGFRA r......
Ponatinib efficiently kills imatinib-resistant chronic eosinophilic leukemia cells harboring gatekee
Objective Like T315I Bcr-Abl, T674I FIP1L1-PDGFRα existed in a subset of chronic eosinophilic leukemia (CEL) is also ga......
Relation and regulatory mechanism between the concentration of Imatinib in bone marrow cells and the
Objective: To determine the relationship of Imatinib (IM) concentration in bone marrow and its therapeutic response in p......
Is imatinib maintenance required for patients with relapse chronic myeloid leukemia post-transplanta
Background: Imatinib is capable of inducing durable molecular responses in relapse chronic myelogenous leukemia (CML) af......
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Folate receptor-targeted liposomes enhanced the antitumor potency of imatinib through the combinatio
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The reduction of tumor interstitial fluid pressure by liposomal imatinib to improve the intratumor d
Interstitial fluid pressure (IFP) in tumor is much higher than that in normal tissue and appears a great obstacle for th......
Imatinib is the standard first line treatment for chronic myeloid leukemia (CML). Owing to doserelated toxicities of Ima......
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目的 建立胃肠道间质瘤耐药细胞模型GIST882-R.方法 采用间歇浓度梯度倍增法体外诱导胃肠道间质瘤细胞株GIST882对Imatinib靶向治......
Gastrointestinal stromal tumor(GIST)is the most common sarcoma of the gastrointestinal tract.Oncogenic KIT or PDGFRA......
Imatinib effects expressions of glycosyltransferases on O-glycan and tumor-associated carbohydrate a
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Gastrointestinal stromal tumor (GIST) with liver metastases an 18-year experience from the GIST Coop
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目的分析国内胃肠间质瘤（GIST）患者伊马替尼服药依从性现状及其影响因素。方法采用横断面调查方法进行问卷调查。调查时间为2020年10......
研究一种酪氨酸激酶抑制剂(tyrosine kinase inhibitor,TKI)伊马替尼(imatinib,IMA)与人血清清蛋白(HSA)及牛血清清蛋白(BSA)的相......
慢性粒细胞白血病 (ＣＭＬ)是由ＢＣＲ ＡＢＬ酪氨酸激酶肿瘤基因表达产物 ,即ｔ( 9;2 2 )Ｐｈ染色体易位引起。ＣＭＬ加速期患者疾病进展迅速 ,对目前的治疗无反......
如众所知,KIT酪氨酸激酶受体持续活化在胃肠道基底细胞癌发病中起关键作用。临床前期研究表明,选择性酪氨酸激酶受体抑制剂Imatin......
细胞表面的糖链参与信号分子识别、细胞间的识别、黏附等多种生物学功能，在肿瘤的侵袭和转移过程中也扮演重要角色。当细胞癌变时，细......
目的建立超高效液相色谱-质谱(UPLC-MS/MS)法测定血浆中伊马替尼浓度的方法。方法以卡马西平为内标,用蛋白沉淀前处理方法。色谱柱......
Expression of c-kit receptor in human cholangiocarcinoma and in vivo treatment with imatinib mesilat
AIM: To investigate the c-kit expression in biliary tract cancer cell lines and histological sections from patients with......
A sensitive, rapid, simple and economical ultra-performance liquid chromatography–tandem mass spectro-metric method (UP......
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目的:本课题选取人慢性粒细胞白血病细胞系K562及其耐药细胞系K562/A02和K562/G01为研究模型,探讨PI3K抑制剂ZSTK474联合酪氨酸激......
目的 探讨伊马替尼联合供者淋巴细胞输注(DLI)治疗异基因造血干细胞移植后慢性粒细胞白血病(CML)复发的效果.方法 3例CML(慢性期)......
在英国每年有 6 0 0人左右患慢性粒细胞白血病 ( CML ) ,到目前为止骨髓移植是唯一的治愈方法。一种新的治疗 CML 的药物称作 imat......
目的:探讨尼洛替尼治疗伊马替尼耐药的慢性髓系白血病(CML)的疗效及安全性。方法:收集伊马替尼治疗失败而接受尼洛替尼治疗的10例......
目的:观察慢性粒细胞白血病患者(CML)服用伊马替尼期间的生育情况。方法:回顾性搜集服用伊马替尼的CML患者或其配偶妊娠过程中疾病......
目的:探讨白藜芦醇对人白血病细胞增殖的影响及机制.方法:采用不同浓度白藜芦醇及伊马替尼对K562细胞进行干预,通过MTT法、台盼蓝......
伊马替尼目前是胃肠间质瘤的一线治疗用药.由于伊马替尼在不同患者体内血药浓度差异较大,目前指南推荐常规监测伊马替尼的血药浓度......
