AGONISTS相关论文
The 3D-QSAR Studies Towards Spingosine-1-Phosphate Receptor 1 Agonists Based on Molecular Docking Al
Spingosine-l-phosphate receptor 1(S1PR1) has attracted significant attention as a target for the treatment of autoimmune......
Design,Synthesis,and Structure-Activities Relationship Studies of α7 Nicotinic Acetylcholine Recepto
Nicotinic acetylcholine receptors(nAChRs)are members of Cys-loop ligand gated ion channels superfamily.The α7 nAChR,a h......
Crystallography-guided discovery of carbazole-based retinoic acid-related orphan receptor gamma-t (R
A series of 6-substituted carbazole-based retinoic acid-related orphan receptor gamma-t (RORγt) modulators were discove......
BACKGROUND Burning mouth syndrome(BMS)is characterized by burning sensation of the oral mucosa.There is a lack of effect......
A common challenge in managing kidney transplant recipients(KTR)is posttransplant diabetes mellitus(PTDM)or diabetes mel......
BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a major chronic liver disorder worldwide,and there is no establishe......
Identification of DK3 As a New Agonist Improving The Transcriptional Functions of Estrogen-Related R
The nuclear estrogen-related receptor α (ERRα) plays a central role in the regulation of expression of the genes i......
Dopamine is found in relatively high levels throughout the insect nervous system and is the most abundant monoamine ......
非酒精性脂肪性肝病现已成为常见的肝脏代谢性疾病，但尚无公认获批的治疗药物上市，探索相关治疗药物迫在眉睫。多项研究结果显示肝脏......
人类尼古丁型乙酰胆碱受体α7亚型是精神分裂认知障碍的治疗靶点,开发具有选择性的激动剂对于该疾病的临床治疗具有重要意义.由于......
PPARs是一类由配体激活的转录因子,属于Ⅱ型核受体超家族成员.PPARs被激活后,能够改善胰岛素抵抗(IR)、纠正脂质代谢紊乱、逆转心......
Aim: To discriminate 32 phenethyl-amines between antagonists and agonists,and predict the activities of these compounds.......
目的探讨Bax表达变化与PPAR-γ激动剂诱导的肺癌细胞凋亡的关系.方法以RT-PCR和Western blot分别检测肺癌细胞株上PPAR-γ的表达,......
目的通过实验大鼠的实验研究对避孕药释放激素的致癌作用进行研究。方法选用TR2近交系大鼠分组选用女性外用避孕药膜,针对不同剂量......
Triptans are 5-hydroxytryptamine 1 B/1 D receptor agonists used in moderate to severe migraine attacks as first line whe......
目的:通过观察肌电图(EMG)的变化,了解运动员与普通中学生在纵跳过程中,膝关节屈伸肌群工作特点,为运动员科学选材提供依据.方法:3......
Effects of glucagon-like peptide-1 receptor agonists on non-alcoholic fatty liver disease and inflam
Glucagon-like peptide1(GLP-1)is secreted from Langerhans cells in response to oral nutrient intake.Glucagon-like peptide......
Splanchnic circulation is the primary mechanism that regulates volumes of circulating blood and systemicblood pressure i......
Novel pharmacological therapy in type 2 diabetes mellitus with established cardiovascular disease: C
Cardiovascular diseases (CVDs) remain the leading cause of death in the world and in most developed countries. Patients ......
阿尔茨海默病（AD）是老年期常见的一类慢性、进行性神经细胞退行性病变。应用毒蕈碱M1受体激动剂是治疗AD的策略之一。M1受体激动剂可......
Recently the field of cholestasis has expanded enormously reflecting an improved understanding of the molecular mechanis......
AIM:To compare gene targeting efficiencies,expression profiles,and Ca2+ handling potentials in two widely used mouse emb......
以章鱼胺能系统为靶标,设计并合成了72个取代苄基亚胺基-2-（口恶）唑烷和取代苯胺基2-（口恶）唑啉化合物。测定了目标化合物对美州大蠊神......
Aim Activation of peroxisome proliferator-activated receptor δ (PPARδ) subtypes increases expression of genes involved......
Possible Role of Exogenous Melatonin and Melatonin-Receptor-Agonists in the Treatment of Menopause―A
One of the core symptoms of the menopausal transition is sleep disturbance. Peri-menopausal women often complain of diff......
Aim: To assess the safety and efficacy of basal-supported prandial GLP-1 receptor agonist therapy (BPT)* in type 2 diabe......
对PPAR-γ的激动剂及其在动脉粥样硬化中对血管细胞的影响等方面进行综述。过氧化物酶体增殖物激活受体-γ（peroxisome proliferato......
促黄体生成激素释放激素（ＬＨＲＨ）活动剂药物已商品化，用于治疗性激素依赖的癌症，ＬＨＲＨ拮抗剂的研究还处于试验阶段。近几年，在寻找高活性，低组胺释放......
Segmental arterial mediolysis: A clinical-pathologic review, its role in fibromuscular dysplasia and
Segmental arterial mediolysis (SAM) is an uncommon non-inflammatory iatrogenic arteriopathy caused by alpha-1 adrenergic......
人体B3上腺素受体（β3AR）激动剂对肥胖症、2型糖尿病、肠蠕动功能障碍、前列腺疾病，异常脂蛋白血症、尿频、尿失禁等疾病的动物模型均......
Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation o
AIM To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability,integrity of t......
Glucagon-like-1 receptor agonists and sodium/glucose cotransporter-2 inhibitors combination—are we e
BACKGROUND The sodium/glucose cotransporter-2 inhibitors(SGLT-2i)and glucagon-like-1 receptor agonists(GLP-1RA)are antid......
Risk of pancreatic adverse events associated with the use of glucagon-like peptide-1 receptor agonis
...
Background and Purpose:Nicotine addiction and abuse remains a global health issue.To date,the fundamental neurobiologica......
Non-alcoholic fatty liver disease(NAFLD)is the predominant cause of chronic liver disease worldwide.NAFLD progresses in ......
Effects of L-Dopa and Dopamine D2 Agonists on Recollection and Familiarity in Idiopathic Nondementin
Idiopathic nondementing Parkinson’s disease (PD) is marked by progressive loss of dopaminergic neurons in the substanti......
Glucagon-like peptide-1(GLP-1)receptor agonists result in greater improvements in glycemic control than placebo and prom......
Cardiovascular death is the leading cause of mortality for patients with type 2 diabetes mellitus. The etiology of cardi......
Background: Non-functioning pituitary adenoma (NFPA) is a challenging tumor. It is usually reached to a large size befor......
Platelets are responsible for blood haemostasis.Although anucleate,a complete translational machinery has been found in ......
