Formaldehyde(FA)has long been considered as a toxin and carcinogen due to its damaging effects to biological macromolecu......

Precise perturbation of protein function with high selectivity and temporal resolution,especially in the gain-of-functio......

The ability to precisely inactivate or modify genes in model organisms helps us understand the mysteries of life.Cluster......

p53 is a key tumor suppressor,and loss of p53 function is frequently a prerequisite for cancer development.The p53 gene ......

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激活标记(activation tagging)技术是以功能获得突变体为研究对象,在植物功能基因组学的研究中具有重要的作用.文章以双子叶模式植......

目的观察SHP-2^D61G/＋酪氨酸磷酸酶激活突变对组织白细胞浸润、细胞因子分泌及多器官损伤的影响。方法分别以SHP-2^D61G/＋激活突变敲......

抑癌基因失活和原癌基因激活共同作用导致了肿瘤的发生。p53基因被认为是目前最重要的抑癌基因,50%人类肿瘤中都携带了能编码p53蛋......

目的：为研究点突变对TP53蛋白的功能的影响，以及突变对肿瘤细胞的作用，并进一步为临床诊断和预后提供支持，进行本课题研究。方法：在人肺......

研究背景:脑胶质瘤是脑内最常见的原发性肿瘤,呈侵袭性生长,恶性程度快速发展,并且复发率和死亡率很高。患者生存期短、预后差,给......