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Detection of EGFR-SEPT14 fusion in cell-free DNA of a patient with advanced gastric cancer: A case r
BACKGROUND Gastric cancer is the fifth most diagnosed cancer worldwide and the third most common cause of cancer-related......
Pancreatic cancer, a highly lethal cancer, has the lowest 5-year survival rate forseveral reasons, including its tendenc......
Combined immune checkpoint inhibitors of CTLA4 and PD-1 for hepatic melanoma of unknown primary orig
BACKGROUND Melanoma is uncommonly found in lymph nodes,subcutaneous tissue,or visceral organs without a primary lesion,w......
One of the serious problems the world is facing today is the antimicrobial resistance on available antibiotics by most b......
The influence of mischmetal addition on physicochemical properties of PtSnNa/ZSM-5 catalyst was studied by means of XRF,......
In order to analyze the complex chemical kinetic mechanism systematically and find out the redundant species and reactio......
The title compound bis-(1,1’-benzotriazoly)-α,ω-decoyldiamide was synthesized by the reaction of benzotriazole with s......
A diabetes mellitus model was established through single intraperitoneal injection of streptozotocin into rats. Seven da......
Effect of gene modified mesenchymal stem cells overexpression human receptor activity modified prote
Objective To investigate the effect of mesenchymal stem cells(MSCs) overexpressing human receptor activity modified prot......
The paper presented first results elaborated during the European Research Project Re-road which aims at the development ......
OBJECTIVE: To explore the relationship between the changes in the activity of caspase-8 and apoptosisof HepG2 cells ind......
AIM:To study oval cells’pathological characteristics andrelationship with the occurrence of hepatocellularcarcinoma(HC......
目的:提取、鉴定陵水暗罗根提取物中挥发性成分,并评价其体外生物活性。方法:采用超临界CO2萃取法提取陵水暗罗根中的挥发性化学成......
血小板在凝血、炎症和免疫反应中起重要作用。血小板质量的变化常常影响着危重症患者的治疗及预后,并与病死率存在明显的相关性。随......
Green synthesis of silver nanoparticles using aqueous extract of saffron (Crocus sativus L.) wastage
Objective: To synthesis silver nanoparticles (AgNPs) by using extract of saffron (Crocus sativus L.) wastages and to tes......
AIM:To investigate the effects of anti-Fas ribozyme onFas expression and apoptosis in primary cultured mousehepatocytes......
Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvemen
AIM: To determine whether ischemic preconditioning (IP) affects the development of edematous cerulein-induced pancreatit......
The quasispecies nature of hepatitis B and C virus (HBV, HCV) plays an important role in the pathogenesis, immune escape......
Protective mechanisms of micro RNA-27a against oxygen-glucose deprivation-induced injuries in hippoc
Hypoxic injuries during fetal distress have been shown to cause reduced expression of micro RNA-27a(mi R-27a),which regu......
Inhibition of histone deacetylase for the treatment of biliary tract cancer:A new effective pharmaco
AIM:TO investigate in vitro and in vivo therapeutic effects of histone deacetylase inhibitors NVP-LAQ824 and NVP-LBH589 ......
Effect of hydroxyapatite nanoparticles on the growth and p53/c-Myc protein expression of implanted h
AIM: To evaluate the effect of hydroxyapatite nano-particles (Nano HAP) by intravenous injection on the inhibition of im......
Inhibition of human La protein by RNA interference downregulates hepatitis B virus mRNA in 2.2.15 ce
AIM:To investigate the role of human La protein in HBVmRNA expression.METHODS:Three human La protein (hLa) specific siR......
Extract of Paris polyphylla Simth Protects Cardiomyocytes from Anoxia-Reoxia Injury through Inhibiti
Objective:To assess any direct effect of extract of Paris polyphylla Simth(EPPS),a Chinese plant,on a cardiomyocyte subj......
[Objective] To investigate the proliferation inhibition and apoptosis in human hepatic cancer cell strain HepG2 induced ......
Yizhijiannao Granule and a combination of its effective monomers,icariin and Panax notoginseng sapon
One of our previous studies showed that Yizhijiannao Granule,a compound Chinese medicine, effectively improved the clini......
Overexpression of cyclooxygenase-2 in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell lines and me
AIM: To investigate the cyclooxygenase-2 (COX-2) expression level in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell l......
Objective: To establish a rat model of warm partial hepatic ischemia-reperfusion (IR), and investigate the protective an......
AIM:To investigate the pathway(s)mediating rat antral circular smooth muscle contractile responses to the cholinomimetic......
AIM: To study the effects of α-pinene on nuclear translocation of nuclear factor-κB (NF-κB) and the expression of th......
AIM: To investigate the influence of C75, a fatty acid synthase inhibitor, on adipocyte differentiation. METHODS: Mouse ......
Anti-asthmatic effects of oxymatrine in a mouse model of allergic asthma through regulating CD40 sig
The aim of the study was to investigate the anti-asthmatic effects of oxymatrine(OXY) and the possible underlying mechan......
Characterization of pumpkin polysaccharides and protective effects on streptozotocin-damaged islet c
The polysaccharides from pumpkin fruit(PP) were obtained and purified by hot-water extraction, anion-exchange chromatogr......
Furfural is an important inhibitor in ethanol fermentation process using lignocellulosic hydrolysates as raw materials.I......
Effect of leukemia inhibitory factor on embryonic stem cell differentiation:implications for support
Aim:Leukemia inhibitory factor (LIF),a pleiotropic cytokine,has been used ex-tensively in the maintenance of mouse embr......
Evaluation of antiviral activities of Houttuynia cordata Thunb.extract,quercetin,quercetrin and cina
Objective:To evaluate the in vitro activities of the ethyl acetate(EA) fraction of Houttuynia cordata(H.cordata) Thunb.(......
One surfactant as sodium dodecyl sulfate (SDS) and one synthesized sample as gas hydrate inhibitor are introduced in th......
Background In a previous study,we have verified that CXCR4 expression is correlated with tumor aggressiveprogression an......
Researchers Reveal the Molecular Basis of the Broad Neutralizing Activity of Human Antibody 3E1 agai
On Dec.2~(nd),2016,a joint team revealed online in Nature Communications that 3E1 could neutralize H1 and H5 subtype vir......
In vitro Metabolism of Strychnine by Human Cytochrome P450 and Its Interaction with Glycyrrhetic Aci
Objective To investigate the metabolism of strychnine(STN)and the metabolic interaction between STN and glycyrrhetic aci......
AIM: Radiation induces an important apoptosis response in irradiated organs. The objective of this study was to investig......
The study of anti-hepatitis drug dimethyl dicarboxylate biphenyl on invasion of human hepatocellular
Objective: To assess the anti-invasive effect of DDB and its possible active mechanism in human hepatocellular carcinoma......
A furano-diterpene(polyalthic acid) was isolated as a major stable compound for the first time from the oleoresin of the......
OBJECTIVE To evaluate the synergistic effect of rosmarinic acid(RA)with antibiotics against Staphylococcus aureus(S.aure......
AIM: To discuss the expression of glactin-3 in liver metastasis of colon cancer and its inhibition by modi- fied citrus ......
The potential molecular mechanism of overexpression of uPA, IL-8, MMP-7 and MMP-9 induced by TRAIL i
BACKGROUND:TNF-related apoptosis-inducing ligand (TRAIL) is a death ligand of the TNF-superfamily that has been implicat......
Effects of different concentrations of celecoxib on proliferation and cell cycle of SH-SY-5Y cells a
BACKGROUND: Highly selective cyclooxygenase-2 (COX-2) inhibitors have recently been approved for the treatment of colon ......
Vascular endothelial growth factor (VEGF) is up-regulated in the vast majority of human tumors. The up-regulation of VEG......
It is quite complex to evaluate the mechanism of action for antitumor drugs on cancer cells.Studies have pointed out tha......
Effects of RNAi-mediated Gene Silencing of LRIG3 Expression on Cell Cycle and Survival of Glioma Cel
The effects of RNAi-mediated gene silencing of LRIG3 expression on cell cycle and survival of human glioma cell line GL1......
Objective:We investigated the influence of CDK1 and CDK2 expression inhibited by cotransfection of CDK1 and CDK2 siRNA o......