OSTHOLE相关论文
Estrogenic activity of osthole and imperatorin in MCF-7 cells and their osteoblastic effects in Saos
There is an increasing interest in phytoestrogens due to their potential medical usage in hormone replacement therapy (H......
Osthole attenuates pulmonary arterial hypertension by the regulation of sphingosine 1-phosphate in r
Osthole is observed to have the capacity to treat pulmonary arterial hypertension (PAH) in rats,but molecular mechanism ......
Osthole decreases collagen Ⅰ/Ⅲ contents and their ratio in TGF-β1-overexpressed mouse cardiac fibrob
The present study was designed to elucidate whether the mechanism by which osthole decreases collagenⅠ/Ⅲ contents and ......
Osthole attenuates vascular remodeling in balloon-injured rats by inhibiting the expression of NF-κB
Aim: To examine the effect of Osthole on vascular remodeling in balloon-injured rats and explore its possible mechanisms......
The coumarin osthole stimulates adult neural stem cells, promotes neurogenesis in hippocampus of the
It is believed that neuronal death caused by abnormal deposition of amyloid-beta (Aβ) peptide is the major cause for th......
Objective: To investigate the effect of Osthole (Ost) on TGF-β1/Smad3 signaling pathway in pulmonary arterial hypertens......
Osthole attenuates the right ventricle remodeling induced by MCT through up-regulated the expression
Aim To investigate the effect of Osthole (Ost) on the right ventricle(RV) remodeling induced by monocrotaline (MCT) in r......
Osthole is one of the major components ofCnidium monnieri (L.) Cuss with the structure of an isopentenoxy-coumarin [1].I......
Osthole exerts an osteoprotective effect in mice model of 5/6 nephrectomy through inhibition of oste
OBJECTIVE:To investigate the effects of osthole on osteoclast formation and bone loss in mice model of 5/6 nephrectomy.M......
Purpose: To determine effectiveness of osthole in retina of a chronic cerebral hypoperfusion (CCH) rat model,and detect ......
Osthole inhibited TGF beta-induced epithelial-mesenchymal transition (EMT) by suppressing NF-κB medi
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Osthole inhibited epithelial-mesenchymal transition(EMT)by suppressing NF-κB mediated Snail activati
Objective: Osthole(OST),an active constituent of Chinese herb Cnidium monnieri,has been reported to inhibit cancer metas......
Osthole inhibits TGF-β1-induced epithelial-mesenchymal transition and suppresses A549 lung cancer ce
Purpose:To understand the suppressive role of osthole on the transforming growth factor-β1(TGF-β1)-induced epithelial-......
Osteoprotective effects of osthole in mice model of 5/6 nephrectomy through inhibiting osteoclast fo
Objective: To investigate the effects of osthole on osteoclast formation and bone loss in mouse model of 5/6 nephrectomy......
Osthole, a main active constituent from Cnidium mon nieri (L.) Cusson, has been considered therapeutic agent in the trea......
OBJECTIVE Pulmonary arterial hypertension(PAH)is a malignant pulmonary vascular disease lacking efficacy therapeutics.Th......
Objective: To investigate the effects of osthole on osteoclast formation and bone loss in mouse model of 5/6 nephrec......
Influence of Temperature on Transdermal Penetration Enhancing Mechanism of Borneol a Multi-scale Stu
The influence of temperature on the transdermal permeation enhancing mechanism of borneol (BO) was investigated usin......
OBJECTIVE:To investigate the effect of osthole on isolated thoracic aortic rings,and to determine the potential mechanis......
The interaction of human serum albumin(HSA) with osthole was investigated by fluorescence spectroscopy.Osthole can quenc......
目的:研究蛇床子素对大鼠胸主动脉的舒张作用并探讨其机制。方法:采用大鼠胸主动脉环张力测定法,观察蛇床子素对苯肾上腺素(PE)和......
目的:研究蛇床子素对人慢性髓系白血病细胞K562增殖和凋亡的影响,并探讨其相关作用机制。方法:培养髓系白血病细胞K562,分别用不同......
目的 探讨蛇床子素对视网膜缺血-再灌注损伤的作用及其潜在机制.方法 大鼠腹腔注射蛇床子素(20、40、80 mg ·kg-1)0.5 h后采用前......
目的研究蛇床子素(Osthole,Ost)对肾上腺皮质功能的影响。方法以Y1小鼠肾上腺皮质瘤细胞为实验对象,以含10%、1%和0.1%血清培养液......
目的 研究口服蛇床子素是否能提高大鼠峰值骨量,从而预防骨质疏松症.方法 1月龄健康SD♀大鼠随机分为2组,每组12只.给药组每日灌服......
目的探讨中药活性成分蛇床子素对抗肿瘤药物TRAIL抗乳腺癌活性的影响并研究其机制。方法用蛇床子素联合TRAIL体外治疗乳腺癌细胞系......
目的探讨蛇床子素对人乳腺癌细胞株MCF-7的作用及其机制。方法对数生长期的MCF-7细胞用0,25,50,100?mol·L?1的蛇床子素处理。细胞......
目的采用HPLC测定妇必舒阴道泡腾片中苦参碱、欧前胡素和蛇床子素的含量。方法苦参碱色谱条件Kromasil100-5 C18色谱柱(250 mm×4.......
目的研究初级纤毛对蛇床子素促进成骨细胞成骨性分化的影响。方法取新生SD大鼠颅骨,多次酶消化法获得成骨细胞,免疫荧光染色观察成......
目的观察蛇床子素在体外抗犬源蓝氏贾第鞭毛虫的作用效果。方法本研究首先分析了不同浓度蛇床子素对犬贾第虫滋养体的生长抑制作用......
Aim: To study the effects of osthole on hyperlipidemic fatty liver and investigate the possible mechanisms. Methods: A r......
Tamoxifen (TMX) is an antiestrogen drug that is used in the treatment and prevention of all stages of estrogen-dependent......
Acetaminophen (APAP) overdose leads to severe hepatotoxicity.Osthole,a natural coumarin found in traditional Chinese med......
目的:建立高效液相色谱法测定复方清带灌注液中苦参碱、槐定碱、蛇床子素的含量。方法:采用HPLC法,苦参碱、槐定碱:色谱柱为氨基键......
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蛇床子素的药代动力学稳定,药理作用广泛,具有较高的潜在开发价值。本文旨在对蛇床子素在大鼠血浆及组织中的药代动力学作一综述,......
Plant pests have been a major problem in agricultural production. To establish sustainable methods for plant pest contro......
目的建立高效液相色谱法同时测定乐舒洗液中小檗碱和蛇床子素的含量。方法采用SPD-20A C18柱为色谱柱,柱温为30℃,流动相为乙腈(A)......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Osthole,an effective monomer in Chinese medicinal herbs,can cross the blood-brain barrier and protect against brain inju......
蛇床子素是从传统的中药蛇床子的果实中提取的香豆素类衍生物.在发达国家以及发展中国家,乳腺癌是发病率和致死率较高的女性肿瘤之......
建立了高效液相色谱法测定败毒散中的5种有效成分,即蛇床子素、二氢欧山芹醇当归酸酯、洋川芎内酯I、洋川芎内酯A和欧当归内酯A。......
AIM: To evaluate the effects of osthole on fatty liver,and investigate the possible mechanism.METHODS: A quail model wit......
采用薄膜-超声分散法制备蛇床子素脂质体,以包封率为评价指标,采用单因素考察和正交试验优化蛇床子素脂质体的处方和工艺条件。所......
目的建立茯蒲洗液中蛇床子素含量测定的高效液相色谱法。方法采用反相高效液相色谱法,以日本DL-C18柱(4.6mm×150mm,5μm)为色谱柱......
Cancer is a serious threat to human life and a big problem in clinical treatment.Some natural active substances extracte......
Cancer is a serious threat to human life and a big problem in clinical treatment.Some natural active substances extracte......
目的建立高效液相色谱法同时测定除湿止汗散中苦参碱和蛇床子素含量的方法。方法色谱条件：色谱柱为DiamonSilC18（2）（250.0mm×4.6m......
目的：建立HPLC法测定非离子型表面活性剂泡囊中蛇床子素的含量。方法：采用Luna C18（250 mm×4.6mm,5μm）色谱柱,以甲醇-水（85∶15）为......
