TGFΒ相关论文
目的 探究APP(淀粉样前体蛋白)的表达在TGFβ诱导的前列腺癌PC-3细胞的迁移和侵袭中的作用.方法 常规培养前列腺癌PC-3细胞后,使用......
目的和内容:骨关节炎(OA)主要表现为进行性的关节软骨丢失。TGFβ/Smad信号通路的激活可以对抗炎症细胞因子介导的软骨组织的降解,在......
研究背景:肌腱损伤是指肌肉或肌腱组织活动过度引起肌腱部位的损伤,治疗后留下的疤痕导致肌腱组织结构变得脆弱容易二次断裂。目前......
钙化性主动脉瓣疾病(Calcific Aortic Valve Disease,CAVD)是当今最常见的心血管疾病之一,给临床治疗和社会经济带来了巨大的负担。......
目的:探讨METTL3对肠癌细胞上皮间质转化及侵袭能力的影响.方法:TGFβ诱导肠癌细胞HCT116和SW480发生上皮间质转化;细胞划痕实验和......
The sensitization and mechanisms of halofuginone in epirubicin resistance of basal like breast cance
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Objective Runt-Related Transcription Factor 1(RUNX1)is highly expressed in the Mes subtype of glioblastoma(GBM).The tran......
目的 胶质母细胞瘤(glioblastoma multiforme,GBM)是常见的中枢神经系统肿瘤,具有恶性程度高、侵袭性强的特性。同时,GBM 具有高度......
目的 肿瘤转移是导致乳腺癌患者死亡的主要原因。流行病学研究发现肥胖是乳腺癌患者预后不良的危险因素,而且代谢重编程是肿瘤的标......
A83-01, a TGFβRI inhibitor, can proliferate adult cardiac progenitor cells and improve cardiac contr
Aim: A population of cardiomyoblast expressing GFP under the regulation of Nkx2.5-enhancer (Nkx2.5-GFP+ cell) was identi......
Cardiac hypertrophy is an adaptive response to the biomechanical stress,but it is the early event to induce cardiomyocyt......
Background:High iodine inhibits papillary thyroid carcinoma cell proliferation associated with TGFβ pathway activation,......
The Relationship between Anti-Vascular Endothelial Growth Factor and Fibrosis in Proliferative Retin
Purpose To investigate the progression of retinal fibrosis after intravitreal bevacizumab injection(IVB)therapy in patie......
Background Secreted frizzled-related protein 1 (sFRP1), Wnt signaling regulator, can positively or negatively regulate t......
Tanshinone Ⅱ A (T Ⅱ A) is widely used for the treatment of various human diseases including diabetic nephropathy (DN)1......
Cardiac hypertrophy is an adaptive response to the biomechanical stress,but it is the early event to induce cardiomyocyt......
Fuling Granule, a Traditional Chinese Medicine Compound,Suppresses Cell Proliferation and TGF β-indu
The compound fuling granule (CFG) is a traditional Chinese drug which has been used to treat ovarian cancer in China for......
TGFβ〈,1〉为一种多肽生长因子,在血小板中含量较高,成熟型TGFβ〈,〉分子量为25KD的同源二聚体,每条肽为12.5KD,在肝纤维化时,TGFβ〈,1〉能显著刺激ECM蛋白在肝脏......
The success of chemotherapy is often limited because of the development of drug resistance.Emerging evidence has shown t......
Smad5 gene is thought to relay signals of bone morphogenetic protein (BMP) pathway.We have previously shown that the......
本文研究制定了对类风湿性关节炎应用清热解素,利湿通路、活性化瘀的治疗方法.通过临床和试验研究,探讨本治法对RA血清VEGF、TGFβ......
Identifying changed protein-protein interactions in biological processes by gene coexpression analys
在 2 蛋白质之间的相互作用力量不在不同条件下面不变却可变。为一个给定的生物过程,在相互作用力量经历动态变化的蛋白质蛋白质相......
目的研究肾皮质细胞膜转化生长因子β(TGFβ)受体(TβR)在大鼠糖尿病发病中的作用。方法观察单侧肾切除后建立的糖尿病大鼠4周后血糖、血胰岛......
TGFβ and Hypoxia Drive Breast Cancer Bone Metastases through Parallel Signaling Pathways in Tumor Ce
Breast cancers frequently metastasize to bone, a site of hypoxia and high concentrations of active TGFβ. Skeletal metas......
AIM: To evaluate the significance of transforming growth factor beta (TGF β) expression, in correlation with histopatho......
骨关节炎(osteoarthritis,OA)是一种最常见的慢性骨关节疾病,可累及整个关节.软骨下骨作为关节的重要组成部分,与OA的发生发展密切......
胚胎着床是哺乳动物妊娠成功建立的关键步骤。随着胚胎在子宫腔上皮的粘附,子宫基质细胞开始由类固醇激素介导的蜕膜化过程,具体表......
研究背景:乳腺癌是目前全球女性发病率最高的一种恶性肿瘤,严重威胁着女性的身体健康。转移是乳腺癌患者死亡的主要原因。乳腺癌具......
研究目的:乳腺癌是目前全球女性较常见的恶性肿瘤之一,其发病率位居女性恶性肿瘤的首位。但是迄今为止我们对乳腺癌的疾病发生发展......
目的:多形性胶质母细胞瘤(glioblastoma multiforme,GBM)是目前最常见的中枢神经系统原发性肿瘤,可发生于任何年龄,约占所有颅内肿......
目的通过检测29份胃癌标本TGF βI和TGF βII型受体的mRNA水平,探讨它们与胃癌浸润和转移的关联性。方法应用点杂交法和计算机灰度......
目的:通过对TGFβⅠ和TGFβⅡ受体的基因表达分析,了解两种受体的基因表达与胰腺癌的相关性。方法:对12例正常胰腺组织和35例胰腺......
TGFβ作为细胞活性多功能的调节因子,它只有刺激细胞增殖,同时又具有抑制细胞增殖的作用。哺乳动物TGFβ共有3种同型体(TGFβ1~3),......
形态学上 ,正常成人肾脏间质的纤维结缔组织很少 ,肾小管之间仅有少量间质分割。肾脏间质对维护正常肾功能非常重要。间质纤维化、......
GDNF家族成员是TGF β生长因子超家族的一个亚家族 ,在神经元的存活 ,生长 ,分化 ,再生 ,轴突生长 ,神经损伤和神经退行性疾病中都......
目的观察表没食子儿茶素没食子酸酯(EGCG)对放射线所致大鼠肺损伤的干预作用,并探讨其可能的作用机制。方法通过6MV X射线复制大鼠......
CAR(CoxsackieBvirusAdenovirusreceptor)是柯萨奇B组病毒 (CoxsackieBvirus,CBV)和腺病毒 (Adenovirus,Ad)与靶细胞结合的共同受......
Restoration of kidney tubular epithelium following sublethal injury seq uentially involves partial epithelial-mesenchyma......
目的 研究TCFβ对树突状细胞的免疫抑制作用及其机制.方法 体外诱导培养CDs,外源性应用TGFβ1,比较各组成熟相关表型的不同,及各组......