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24. The transcription factors and the relevant signaling pathways activated by low concentration MNN
Aims: To explore the transcription factors and related signal transduction pathways activated in the alkylating agents N......
29. LACK OF ASSOCIATION OF AH RECEPTOR GENE POLYMORPHISM WITH SUSCEPTIBILITY TO BLADDER CANCER IN SH
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Nullbasic is a mutant form of HIV-1 Tat that has strong ability to protect cells from HIV-1 replication by inhibiting th......
Downregulation of miR-17~92 expression increase paclitaxel sensitivity in human ovarian carcinoma SK
To better understand the molecular mechanisms of paclitaxel resistance in ovarian carcinoma, we evaluated the expression......
Glycyrrhiza inflata Bat.is most salt tolerance among three authentic medicinal licorices in China.It mainly distributed ......
<正> It is well established that adenosine triphosphatase （ATPase） complex is an important assembly for bioenergy transduc......
An EST （gb/AA115239） with high identity to the mouse cytokine signal transduction inhibitor gene mmSOCS-2 was selected in ......
Heregulin-α (HRGα) is a cytokine secreted by the mammary mesenchyme, adjacent to lobuloalveolar structures. To underst......
Tumor necrosis factor (TNF) is an important cytokine with multiple biological effects,including cell growth,differentiat......
AIM: To study the 5-HT responses in stomach fundus from Steptozotocin (STZ)-induced diabetic rats in comparison with ca......
苏云金芽孢杆菌(Bacillus thuringiensis)能产生杀虫晶体蛋白等多种活性成分,是目前应用最广泛的微生物杀虫剂。本文采用生物信息......
Tumor-infiltrating lymphocytes (TIL) were once considered as the effector cells in the immune attack against cancer.Howe......
Label-free fluorescent strategy for sensitive detection of tetracycline based on triple-helix molecu
In this assay, a label-free fluorescent sensing platform based on triple-helix molecular switch(THMS) and G-quadruplex w......
Aim:To test whether the neurogenic differentiation(NeuroD)protein could alle-viate symptoms of diabetes mellitus by its......
AIM:To study the effect of cholecystokinin-octapeptide(CCK-8)on lipopolysaccharide(LPS)-induced pulmonaryartery smooth ......
In the present study, a rat model of type 2 diabetes mellitus was established by continuous peritoneal injection of stre......
A therapeutic anti-CD4 monoclonal antibody inhibits T cell receptor signal transduction in mouse aut
Background T cell immune abnormalities in patients with dilated cardiomyopathy(DCM)has been intensively studiedover the......
Objectives To investigate the effect of Gαq/11 signaling pathway and ATP-sensitive potassium channel ( KATP channel ) o......
Effect of the cyclic stretch and role of related signal pathway on the osteogenic differentiation of
Mechanical strain stimulation is one of the important factors to regulate bone metabolism,maintain bone mass and bone st......
Biased ligand bonds to make right calls—laboratory of signal transduction reveals molecular mechanis
In a recent study,Professor Rui-Ping Xiao and her research group at Institute of Molecular Medicine of Peking University......
An experiment was conducted to investigate the response of salicylic acid as a second messenger to the heat stress in gr......
Protein kinase small molecule inhibitors for rheumatoid arthritis: Medicinal chemistry/clinical pers
Medicinal chemistry strategies have contributed to the development, experimental study of and clinical trials assessment......
Objective To investigate the effects of bone morphogenetic protein-7(BMP7)on insulin signaling transduction in C2C12 myo......
Inhibition of the growth of human hepatoma cell line both in vitro and in vivo by transducing CKI ge
The EGF receptor-mediated targeting gene delivery system GE7 was used to transduce exogenous gene pCEP-p21WAF-1 into hu......
To investigate the role of bax in a vincristine (VCR) induced multidrug resistant (MDR) human gastric cancer cell line......
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AIM:To investigate gap junctional intercellularcommunication (GJIC) in hepatocellular carcinoma celllines,and signal tr......
AIM:To investigate the expression of NGF family and theirreceptors in gastric carcinoma and normal gastric mucosa,and t......
OBJECTIVE: To explore the relationship between the changes in the activity of caspase-8 and apoptosisof HepG2 cells ind......
In order to explore the effects of irradiation-inducing on the transduction of Ad-CMV-p53, human hepatoma (HepG2 line) c......
Objective To explore JunB gene expression in spleen cells of mice after the whole body irradiation as well as in normal......
Effect of mitogen-activated protein kinase signal transduction pathway on multidrug resistance induc
AIM:To investigate the correlation between mitogen-activated protein kinase (MAPK) signal transduction pathwayand multi......
Effects of PI3K and p42/p44 MAPK on overexpression of vascular endothelial growth factor in hepatoce
AIM:To study the relationship between hypoxia or epidermalgrowth factor (EGF) and the overexpression of vascularendothe......
Aim: To search genes sensitivity to the anti-cancer drugs navelbine (NVB) and docetaxel (DOC) in small-cell lung cancer......
Mitogen activated-protein kinases(MAPKs)are important components in signal transduction pathways responding to various b......
Migration to gliomas of bone mesenchymal stem cells transfected with cytosine deaminase gene followi
This experiment sought to observe the migration and distribution of bone mesenchymal stem cells transfected with the cyt......
IDDM results from pancreatic beta cell destruction by islet-reactive T cells, a process that involves beta cell apoptosi......
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Hypoxia-inducible factor 1 (HIF-1) attenuates amyloid-beta protein neurotoxicity and decreases apoptosis induced by oxid......
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TransductionofhumanhepatocelularcarcinomacelswithhumanγinterferongeneviaretroviralvectorQIANShuBin......
Suppression of P-gp induced multiple drug resistance in a drug resistant gastric cancer cell line by
AIM To observe the drug sensitizing effect andrelated mechanisms of fas gene transduction onhuman drug-resistant gastri......
To study on the effect of low dose irradiation (LDI) on expression of membrane molecules of T lymphocytes in cord blood......
Objective: To investigate the regulation effect of protein kinase A on IL-6-induced STAT3 activation in myeloma cells. M......
CCK-8 inhibits expression of TNF-α in the spleen of endotoxic shock rats and sigual transduction mec
AIM:To study the effect of sulfated cholecystokinin-octapeptide(CCK-8)on systemic hypotension,gene andprotein expressio......
Mechanism of macrophage injury following traumatic hemorrhagic shock: through PTX-sensitive G-protei
Objective: To study the mechanism of macrophage injury after trauma-hemorrhagic shock. Methods: Wistar male rats und......
Anti-intlammatory effect of cholecystokinin ana its signal transduction mechanism in endotoxic shock
AIM:To study the anti-inflammatory effects ofcholecystokinin-octapeptide(CCK-8)onlipopolysaccharide(LPS)-induced endoto......
Influence of Kupffer cells on hepatic signal transduction as demonstrated by second messengers and n
AIM:To understand the influence of Kupffer cell (KC) onsignal transduction pathways in the liver.METHODS:To decrease se......
AIM:To prepare and purify TAT-HBV targeted ribonucleasefusion protein,evaluate its transduction activity andinvestigate......
Protein kinase C-dependent activation of P44/42 mitogen-activated protein kinase and heat shock prot
AIM:To investigate the significance of protein kinase C(PKC),P44/42 mitogen-activated protein kinase (MAPKs)and heat sh......
AIM:Cytotoxic T lymphocytes (CTLs) play an important rolein resolving HBV infection.In the present study,weattempted to......
Vascular contractile response and signal transduction in endothelium-denuded aorta from cirrhotic ra
AIM: The mechanism of decreased vascular reactivity to vasoconstrictors in portal hypertension is still unclear. In addi......
