TUMORIGENESIS相关论文
人类微小RNA（microRNA,简称miRNA）通过和Ago2蛋白结合形成RISC复合物（RNA-induced silencing complex）,介导mRNA降解和抑制mRNA翻译,发......
Bcl-2 Interacts with Beclin 1 and Regulates Autophagy in 7,12-Dimethylbenz[a]anthracene-Induced Hams
Objective:Autophagy is a programmed cell death procedure,which has essential functions in tumorigenesis.However,its temp......
Comparison of gene expression of the oncogenic Wnt/β-catenin signaling pathway components in the mou
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Carbon nanomaterials including carbon nanotubes(CNTs)have increasing been used for a variety of commercial and biomedica......
Bisphenol A modulates colorectal cancer protein profile and promotes the metastasis via induction of
More and more evidences indicate that endocrine disruptor chemicals (EDCs) such as bisphenol A (BPA) can act as carcinog......
Aim: To investigate the combinatorial anti-tumorigenesis and anti-osteoclastogenesis effects of plumbagin and zoledronic......
Objective PURPOSE:To examine the role of miR-106b-5p in regulating the cancer stem-cell-like phenotype in clear cell ren......
Oncostatin M Receptor,positively regulated by SP1,promotes gastric cancer growth and metastasis upon
目的 Oncostatin M receptor(OSMR)is a member of the interleukin 6(IL-6)receptor family that transduces signaling events o......
CircRNA expression and the association with clinicopathological characteristics in human papillary t
Objective Papillary thyroid carcinoma(PTC)is the most common type of thyroid cancer.CircRNA is a novel class of RNA that......
Dysregulation of the miR-139-5p-TRIM24 negative feedback loop drives tumorigenesis in colorectal can
Objective Increasing evidence highlights the important roles of TRIM24(Tripartite motif containing 24)in tumor initiatio......
Long noncoding RNA OR3A4 promoted the growth and tumorigenicity by targeting PDLIM2,MACC1,NTN4 and G
Objective: Iymph node metastasis is a major way in gastric cancer.The contributions of long noncoding RNAs(IncRNAs)to th......
The conventional strategy for cancer therapy offers limited control of specificity and efficacy, study on the molecular ......
HHLA2,as an immunoregulatory protein and tumorassociated antigen,promotes non-small cell lung cancer
Objective Non-small cell lung cancer(NSCLC)is the most common cancer worldwide and bears the highest mortality rate.The ......
Background: Pre-B-cell leukemia homeobox 1(PBX1)was originally identified as a proto-oncogene in human leukemia....
The promotion of the transformation of quiescent gastric cancer stem cells by IL-17 and the underlyi
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“Lianhua Shenjia” formula Prevents 4-Nitroquinoline 1-Oxide Induced Esophageal Tumorigenesis in Mice
Esophageal squamous cell carcinoma (ESCC) patients always had a poor prognosis, because they were diagnosed at a later s......
BCKDK promotes colorectal cancer tumorigenesis via directly activating MEK1 at Ser221,and phenylbuty
Background & Aims: Colorectal cancer(CRC)is the third most commonly diagnosed cancer in males and the second in females.......
Despite the fundamental importance of proteasomal degradation in cells,little is known about whether and how the 26S pro......
Cell-based studies showed that several Mdm2-binding ribosomal proteins, upon overexpression, stabilize and activate p53.......
Somatic mutation and altered protein expression patterns cause inappropriate activation and deactivation of key players ......
Tumorigenesis relies on the change of protein structure,modification and dosage.Modest protein dosage is indispensable f......
Objective Gastric cancer is one of the most common types of cancer worldwide,and it involves extensive local tumor invas......
Chemotherapy is a main category of cancer treatment that aims to prolong life or to reduce symptoms.Besides blocking cel......
33-kDa annexin A3 isoform promotes HCC and its knockdown suppresses tumorigenesis and malignancy via
Hepatocellular carcinoma(HCC)is the third leading cause of most common cancer-related deaths due to its higher metastasi......
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H3K9 Demethylases Disable Oncogene-Induced Senescence and Serve As Therapeutic Targets For Senescenc
Cellular senescence is a stable cell-cycle arrest,which can be induced by over expressio no fonco genes,genetic mutatios......
MTA1 promotes tumorigenesis and development of esophageal squamous cell carcinoma via activating MEK
Objective Metastasis-associated protein 1(MTA1)has been reported to be upregulated in multiple malignancies and promotes......
The conventional strategy for cancer therapy offers limited control of specificity and efficacy,study on the molecular m......
Background: Most renal cell carcinoma (RCC) occur in one kidney;however, in a small set of patients (0.7-4.7%), RCCs occ......
Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis
The mammalian target of rapamycin (mTOR) signaling pathway is upregulated in the pathogenesis of many cancers.Arachidoni......
Circadian oscillation and cell cycle progression are the two most essential rhythmic events present in almost all organi......
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H3K27 Trimethylation is an Early Epigenetic Event of p16NK4a Silencing for Regaining Tumorigenesis i
Stable epigenetic silencing of p16INK4ais a common event in hepatocellular carcinoma (HCC) cells,which is associated wit......
FTO,the first m6A demethylases,has been reported to regulate tumorigenesis of glioblastoma stem cells [1] and melanoma [......
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The role of ALDH2 in tumorigenesis and tumor progression:Targeting ALDH2 as a potential cancer treat
A major mitochondrial enzyme for protecting cells from acetaldehyde toxicity is aldehyde dehydrogenase 2 (ALDH2).The cor......
Esophageal squamous cell carcinoma(ESCC)is the major subtype of esophageal cancer that is prevalent in Eastern Asia.Desp......
Neuromedin B(NMB)is a member of mammalian bombesin-like peptide family and almost all its potent biological actions take......
The delicate balance between self-renewal and differentiation needs to be exquisitely regulated to maintain tissue h......
Macrophages are dominant leukocyte population in tumor microenvironment and actively promote cancer progression.Howe......
PIWI proteins are known to enlist germline-specific Piwi-interacting RNAs(piRNAs)to suppress transposable elements a......
The Mediator complex orchestrates multiple transcription factors with the Pol Ⅱ apparatus for precise transcription......
Isocitrate dehydrogenase (IDH), as an old housekeeping gene and a popular star, drawing more and more attention of c......
