priOn相关论文
The 37/67-kDa laminin receptor precursor (LRP)/laminin receptor (LR) is a cell surface receptor for cellular prion prote......
Objective: AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy by phosphorylating U......
The cellular hallmarks of Parkinsons disease(PD)are the loss of nigral dopamine neurons and the formation of α-synuclei......
Growth phase-dependent changes in the size and infectivity of SDS-resistant Sup35p assemblies associ
The translation termination factor Sup35p can form self-replicating fibrillar aggregates responsible for the [PSI+] prio......
Objective To find the different electrophoretic profiles of prion protein in carcinous and individual pericarcinous tiss......
Tumor Necrosis Factor a Reduces SNAP29 Dependent Autolysosome Formation to Increase Prion Protein Le
Tumor Necrosis Factor α(TNFα) is best known as a mediator of inflammation and immunity, and also plays important roles......
Crystallization and preliminary X-ray crystallographic analysis of yeast prion protein Ure2p with sh
An orthorhombic crystal form of a recombi-nant yeast prion protein with shortened N-terminal, 90Ure2p, has been obtained......
In prion diseases the irreversible protein structural transformation process is completed in the brains of mammals withi......
Homochiral expression of proteins:a discussion on the natural chirality related to the origin of lif
Homochirality in life has always been a driving force in scientific research and natural exploration. It has not been sa......
Cellular prion protein imaging analysis with aptamer-labeled Ru(bpy)_3~(2+)-doped silica nanoparticl
A new type of highly selective aptamer-labeled fluorescent silica nanoparticles[Apt-tris(2,20-bipyridyl)ruthenium(II)@Si......
Prion diseases are a group of neurodegenerative diseases that are fatal. The study of these unique diseases in China is ......
关于Ｐｒｉｏｎ汉译名的建议贲昆龙张永振（中国科学院昆明动物研究所，昆明６５０２２３）关键词ｐｒｉｏｎ汉译名１９９７年的诺贝尔生理学与医学奖授予加利福尼亚大学旧金山分校......
1997年10月6日,美国加州大学旧金山医学院的普鲁西纳教授获得了100万美元的本年度诺贝尔生理学奖与医学奖。这是因为他在研究朊病......
Objective: AMPK is a serine/threonine protein kinase that acts as a positive regulator of autophagy by phosphorylati......
目的本试验通过已建立的ScN2a细胞模型,探讨阿魏酸对朊病毒复制的影响。方法通过Western blot法检测阿魏酸对朊病毒复制作用的影响......
图中这位从瑞典国王手中接过荣誉证书的人就是1997年度诺贝尔生理学或医学奖得主,美国加州大学旧金山分校的史坦利·布鲁希纳(Stan......
Prion diseases are infectious and fatal neurodegenerative diseases. The pathogenic agent is an abnormal prion protein ag......
采用免疫组织化学和图像分析技术，对39例胶质瘤中阮病毒蛋白（Prionprotein，PrP）的表达进行了定量研究。结果发现，PrP在各级胶质瘤中有不......
尽管新技术让生活更美好,但新技术的复杂性也偶尔会使其在应用中遇到阻力。新技术的开发既要有创新又要直观,这对聪明的设计人员......
疯牛病已经是现代社会影响人们健康和社会经济的一种重要动物疫病，为此日本直到现在还未解禁对美国的牛肉进口。如今，北美的加拿大和......
已知羊瘙痒病(scrapie)与人类震颤病(kuru)和CJD等神经系统慢感染的病原体与典型病毒不同。关于其本质,迄今尚无定论。Prion是从感......
已知羊瘙痒病(scrapie)与人类震颤病(kuru)和CJD等神经系统慢感染的病原体与典型病毒不同。关于其本质,迄今尚无定论。Prion是从感......
近年来,发生于英国的疯牛病迅速跨越疆土,传遍整个欧洲大陆,目前已使数百万头牲畜遭受灭顶之灾,不仅如此全球已经发现近100例变异......
在有人类之前,微生物早就存在,因此,从人类出现时起,微生物就在人群中适应这种连续的变化,这种适应性仍在继续下去。远古在世界的......
1病例报告林某某，男性，19岁，英籍华人，因四肢乏力、不自主抽动，记忆力减退1年，言语不清半年余于1997年11月19日入院。既往无特殊病史，无器......
朊病毒病（Prion disease）又称海绵状脑病,是一组具有传染性和遗传性的神经变性性疾病。典型的病理变化局限在中枢神经系统,由神经细......
加利福尼亚大学医学院的 stanley pruisner 提出“当脑结构崩溃和变性时,将会发生什么?”的问题。例如,在全世界约有百万分之一的......
Abnormal protein aggregation or amyloid is the major cause of many neurodegenerative disorders. The present review focus......
人类基因测序工程的完成,启动了对生命本质的认识,也标志着大规模研究蛋白质生物学时代的到来.人类基因组测序工程尚不能在蛋白分......
朊病毒(Prion)并非病毒,也不是类病毒,是一种特殊的具有感染性的蛋白质,简称PrP。由它引起的疾病称朊病毒病。人类朊病毒病主要指......
Prion病是指一组可传递的海绵状脑病 ( transm issiblespongiform encephalopathy,TSE)。大量研究表明该病是一种称为朊蛋白 ( pri......
Prion病是指一组可传递的海绵状脑病 ( transm issiblespongiform encephalopathy,TSE)。大量研究表明该病是一种称为朊蛋白 ( pri......
朊蛋白病是由异常朊蛋白在脑内蓄积所致。本文综述了朊蛋白的生化特性、异常朊蛋白形成机制、正常朊蛋白向异常朊蛋白转变机制、朊......
CJD是一种人类传染性海绵状脑病,它有医源型(1-5％)。散在型(80～90％)和家庭型(5～15％)其传染因子似是异常同种型的朊病毒(Prion)蛋白(PrP......
朊病毒是一类可传递的蛋白质感染颗粒,似乎仅仅由一种修饰后的蛋白PrP~(Sc)构成。PrP~(Sc)由正常细胞蛋白prp~(c)通过翻译后加工、......
Dynamic Analyses of PrP and PrP~(Sc) in Brain Tissues of Golden Hamsters Infected With Scrapie Strai
Objective To expatiate dynamic changes in hamsters infected with scrapie strain 263K, to observe the presence and aggra......
克-雅氏病,亦称亚急性海绵状脑病(Subacute Spongi- form Encephalopathy,SSE)或称为皮质-纹状体-脊髓变(cor- ticol-Striatd-Spin......
朊毒体病(prion disease)是一类人和动物的慢性中枢神经系统退行性疾病,其中人类朊毒体病包括库鲁病,克雅病(CJD),杰茨曼-斯脱司勒......
Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion
AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies ......
Helicobacter pylori upregulates prion protein expression in gastric mucosa: A possible link to prion
AIM: Pathological prion protein (PrPSC) is responsible for the development of transmissible spongiform encephalopathies ......
Establishment of a Stable PrP~(Sc) Panel from Brain Tissues of Experimental Hamsters with Scrapie St
Objective To establish a stable PrPSc panel from brain tissues of experimental hamsters infected with scrapie agent 263K......
克—雅病(Creutzfeldt-Jakob Diseaae CJD)是发生在人类由朊蛋白(Prion)引起的以海绵样变性为病理特征的亚急性或慢性海绵样脑病。......
为进一步确定PrP蛋白与14-3-3蛋白是否发生分子间的相互作用并确定PrP蛋白与14-3-3蛋白相互作用的区域,利用免疫共沉淀、pull down......
Neurodegenerative disorders,including Alzheimer’s disease(AD) and Parkinson’s disease(PD),are common disorders of the ......
