pyroptosis相关论文
Disulfiram, an aldehyde dehydrogenase inhibitor, works as a potent drug against sepsis and cancer vi
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目的:探究晶状体上皮细胞焦亡在糖尿病性白内障发生中的可能作用。方法:实验研究。选择2020年3至11月就诊于天津医科大学眼科医院......
Objective:To determine whether salvianolic acid B(Sal B)exerts protective effects on diabetic peripheral neuropathy by a......
Induction of multiple subroutines of regulated necrosis in murine macrophages by natural BH3-mimetic
Macrophages are critical sentinel cells armed with multiple regulated necrosis pathways,including pyroptosis,apoptosis f......
Glioblastoma multiforme(GBM)is the most malignant and lethal primary brain tumor in adults accounting for about 50％of all......
H7N9 virus infection triggers lethal cytokine storm by activating gasdermin E-mediated pyroptosis of
The H7N9 influenza virus emerged in China in 2013,causing more than 1560 human infections,39％ of which were fatal.A\'cy......
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目的:评价肝缺血再灌注大鼠外泌体对小胶质细胞焦亡的影响。方法:清洁级健康雄性SD大鼠20只，2~3周龄，体重20~50 g，采用随机数字表法分......
Exosomes derived from bone marrow mesenchymal stem cells protect the injured spinal cord by inhibiti
Mesenchymal stem cell (MSC) transplantation is a promising treatment strategy for spinal cord injury, but immunological ......
Molecular mechanism and therapeutic targeting of necrosis, apoptosis, pyroptosis, and autophagy in c
Cell death occurs in various tissues and organs in the body. It is a physiological or pathological process that has diff......
Pyroptosis is the process of inflammatory cell death.The primary function of pyroptosis is to induce strong inflammatory......
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lncRNA KCNQ1OT1 contributes to malignant biological behaviors of human glioblastoma multiforme cells
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5-aminolevulinic acid hydrochloride loaded microbubblesmediated sonodynamic therapy in pancreatic ca
Objective Pancreatic cancer has a particularly high mortality and a low survival rate among the major malignancies.Conve......
Interferon Regulatory Factor-1 Mediates Alveolar Macrophage Pyroptosis During LPS-Induced Acute Lung
目的 Previously,we demonstrated that pyroptosis in alveolar macrophages(AMs)plays an essential role in LPS-induced acute......
Benzene and its metabolite trigger cell pyroptosis death via TET2 directly regulating Aim2/Casp1 pat
Long term low-dose benzene exposure lead to the inhibition of hematopoiesis causing a decrease of peripheral blood cell ......
Switch off “Parallel Circuit”:Insight of New Strategy of Simultaneously Suppressing Canonical and No
Sepsis is a life-threatening inflammatory disease with a high mortality rate and huge implicative cost.Lipopolysaccharid......
Application of non-canonical crosslinking amino acids to study pyroptosis related protein-protein in
Pyroptosis is a form of regulated cell death in mammalian cells that is triggered by activation of various inflammasome ......
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Inhibition of Alveolar Macrophage Pyroptosis Reduces Lipopolysaccharide-induced Acute Lung Injury in
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Tangshenping granule inhibits pyroptosis in a rat model of streptozotocin-induced diabetic nephropat
Objective:To explore the inhibitory effect of Tangshenping (TSP) on pyroptosis in a streptozotocin-induced diabetic neph......
目的检测caspase-4、caspase-5、gasdermin D(GSDMD)、核苷酸结合寡聚化结构域NOD样受体蛋白质3(nucleotide-binding oligomerizat......
Macrophage membrane-mediated targeted drug delivery for treatment of spinal cord injury regardless o
Targeted delivery of therapeutics for spinal cord injury(SCI)has been a long-term challenge due to the complexity of the......
Caspase-11/4 and gasdermin D-mediated pyroptosis contributes to podocyte injury in mouse diabetic ne
Diabetic nephropathy(DN)is characterized by sterile inflammation with continuous injury and loss of renal inherent paren......
目的探究碘化钾诱导甲状腺滤泡细胞焦亡的分子机制。方法ELISA检测桥本甲状腺炎合并甲状腺癌组织中焦亡指标白细胞介素(interleuki......
细胞焦亡是一种继细胞凋亡、细胞坏死及自噬之后新发现的炎性体介导的程序性促炎性反应造成细胞死亡方式，其主要信号通路包括依赖半......
调节性坏死是新发现的新型细胞死亡途径，包括程序性坏死、细胞焦亡、铁死亡等。有研究报道，调节性坏死在缺血/再灌注、顺铂等药物、......
细胞凋亡是造成人类免疫缺陷病毒(HIV)感染者CD4T细胞耗竭的一个关键机制,但对其具体信号通路知之甚少。该研究表明,caspase-3介导......
细胞焦亡作为一种新的促炎程序性细胞死亡方式被逐渐研究阐述，其形态学特征、发生机制、作用机制与其他细胞死亡方式（如凋亡、坏死等......
目的观察线粒体DNA（mtDNA）对脂多糖（LPS）诱导的大鼠肺泡巨噬细胞炎症反应的放大作用，并初步探讨其可能机制。方法提取SD大鼠肝脏组织mtD......
脓毒症是由感染引起的宿主免疫反应异常而导致的威胁生命的器官功能障碍综合征。细胞焦亡是新近发现的一种依赖天冬氨酸特异性半胱......
<strong>Background: </strong>Pyroptosis is defined as programmed necrosis executed by gasdermin D or E (GSDMD or GSDME),......
L-carnitine protects against tacrolimus-induced renal injury by attenuating programmed cell death vi
Reducing immunosuppressant-related complications using conventional drugs is an efficient therapeutic strategy.L-carniti......
Programmed cell death(PCD),including apoptosis,apoptotic necrosis,and pyroptosis,is involved in various organ dysfunctio......
Lysosome is a ubiquitous acidic organelle fundamental for the turnover of unwanted cellular molecules,particles,and orga......
Scutellarin inhibits caspase-11 activation and pyroptosis in macrophages via regulating PKA signalin
Inflammatory caspase-l1 senses and is activated by intracellular lipopolysaccharide(LPS)leading to pyroptosis that has c......
BIX-O1294-enhanced chemosensitivity in nasopharyngeal carcinoma depends on autophagy-induced pyropto
Nasopharyngeal carcinoma (NPC) is a common cancer in southern China and Southeast Asia.Nowadays,radiotherapy is the ther......
Objective: Nucleotide binding oligonucleoid-like receptor 3 (NLRP3), caspase-1 (caspase-1) and interleukin-1β (IL-1β) ......
TP53-induced glycolysis and apoptosis regulator alleviates hypoxia/ischemia-induced microglial pyrop
Our previous studies have demonstrated that TP53-induced glycolysis and apoptosis regulator (TIGAR) can protect neurons ......
Stroke is an acute cerebro-vascular disease with high incidence and poor prognosis,most commonly ischemic in nature.In r......
CD4~+T细胞是HIV-1感染的主要靶细胞。HIV-1感染导致CD4~+T细胞数量减少,宿主免疫功能缺陷,是艾滋病的主要发病机制。大量的研究发......
目的探讨血浆中细胞外组蛋白能否通过介导外周血单个核细胞（PBMC）焦亡加重急性呼吸窘迫综合征（ARDS）患者炎症反应。方法选择2019年4月......
Eukaryotic elongation factor-2 kinase (eEF-2K),a negative regulator of protein synthesis,has been shown to play an impor......
Pyroptosis is a form of programmed cell death,and recently described as a new molecular mechanism of chemotherapy drugs ......
Upregulation of miR-133a by adiponectin inhibits pyroptosis pathway and rescues acute aortic dissect
Acute aortic dissection (AAD) is a cardiovascular emergency caused by the formation of hematoma in the middle layer of t......
Gasdermins (GSDMs) belong to a protein superfamily that is found only in vertebrates and consists of GSDMA,GSDMB,GSDMC,G......
细胞焦亡是近年来发现并证实的一种新的程序性细胞死亡方式,其特征为依赖于半胱天冬酶-1(caspase-1),并伴有大量促炎症因子的释放.......
