猪繁殖与呼吸综合征病毒非结构蛋白7的基因变异分析

来源 :2013国际猪繁殖与呼吸综合征学术研讨会 | 被引量 : 0次 | 上传用户:p2908892
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引言 猪繁殖与呼吸综合症病毒的非结构蛋白对于病毒的复制具有很重要的作用.目前Nsp7的结构及其在PRRSV复制周期中的作用尚未明确,研究显示Nsp7抗体产生时间早,抗体水平高,持续时间长,表明Nsp7与机体免疫应答关系较为密切.由于Nsp7基因在Nsp中相对保守,不同病毒株之间差异变化较小,因此适于作为检测抗原检测不同病毒株的抗体水本研究.本研究将通过对Nsp7进行突变和缺失来探索Nsp7蛋白质的结构与功能.
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