【摘 要】
：
Human hepatoma (HCC) has been reported to be strongly resistant to Fas-mediated apoptosis.However, the underlying mechanisms are poorly understood.In this study
【机 构】
：
KeyLaboratoryofFunctionalProteinResearchofGuangdongHigherEducationInstitutes;DepartmentofBiotechnolo
【出 处】
：
2014年第十二届全国脂质与脂蛋白学术会议
论文部分内容阅读
Human hepatoma (HCC) has been reported to be strongly resistant to Fas-mediated apoptosis.However, the underlying mechanisms are poorly understood.In this study, the function of OSBP-related protein 8 (ORP8) in human hepatoma cells apoptosis was assessed.We found that ORP8 is down-regulated while miR-143, which controls ORP8 expression, is up-regulated in clinical HCC tissues as compared with liver tissue from healthy subjects.ORP8 overexpression triggered apoptosis in primary HCC cells and cell lines, which coincided with a relocation of cytoplasmic Fas to the cell plasma membrane and FasL up-regulation.Co-culture of HepG2 cells or primary HCC cells with Jurkat T-cells or T cells, respectively, provided further evidence that ORP8 increases HCC cell sensitivity to Fas-mediated apoptosis.FasL was induced upon ORP8 overexpression via the ER stress response.
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