【摘 要】
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Silica-based materials,especially the nanostructured silica materials,including monodispersed silica nanoparticles,silica-coated functional nanoparticles and mesoporous silica nanoparticles,are of gre
【机 构】
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Lab of Low-Dimensional Materials Chemistry,School of Materials Science and Engineering,East China Un
【出 处】
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中国微米纳米技术学会纳米科学技术分会第四届年会暨2016国际纳米生物与医学学术会议
论文部分内容阅读
Silica-based materials,especially the nanostructured silica materials,including monodispersed silica nanoparticles,silica-coated functional nanoparticles and mesoporous silica nanoparticles,are of great importance based on their easy and low-cost preparation,tunable particle sizes,chemical stability,facile surface functionalization and broad potential applications in biomedicine.[1] Furthermore,the negligible cytotoxicity has rendered them widely used auxiliary components,e.g.food additives and vitamin supplements,which have been approved by the US Food and Drug Administration(FDA).Although significant progresses on various silica-based nanothernostic systems have been made,there are still a number of key challenges including unsatisfactory guest molecules/nanoparticles loading amounts,long-term stability in biological environment and potential bio-toxicity remaining to be solved,which have greatly hampered its clinical transformation.
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