• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 会议论文
  5. Domain interaction and functional modification of mechanosensitive channel MscL

Domain interaction and functional modification of mechanosensitive channel MscL

来源 :The 4th International Ion Channel Conference(第四届国际离子通道会议) | 被引量 : 0次 | 上传用户：shi_shui_wen
【摘 要】
：
The mechanosensitive channel of large conductance (MscL) acts as a biological "emergency release valve" that protects bacterial cells from hypoosmotic stress, has become a paradigm of how a mechanosen
【作 者】
：
Yuezhou Li Paul Blount 
【机 构】
：
Zhejiang University School of Medicine, China Uni
【出 处】
：
The 4th International Ion Channel Conference(第四届国际离子通道会议)
【发表日期】
：
2013年2期
【关键词】
：
mechanosensitive channel 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
The mechanosensitive channel of large conductance (MscL) acts as a biological "emergency release valve" that protects bacterial cells from hypoosmotic stress, has become a paradigm of how a mechanosensitive channel can sense and respond to membrane tension.Here, we present our studies about transmemebrane domain interaction and functional modification of mechanosensitive channel MscL: 1.
其他文献
Im58, a new toxin from the Scorpion Isometrus maculates venom, potently and selectively blocks Kv1.3
Kv1.3 channels have become a novel target for the treatment of autoimmune diseases.Searching for specific Kv1.3 potassium channel inhibitors has become the current hot spot for the treatment of autoim
会议
Isometrus maculatesIm58Kv1.3 channelsautoimmune diseases
PIP2 Dependent and Independent Motions of N/CTerminus Open the Kir Channels
Inward rectifier potassium (Kir) channels regulate cell resting membrane potential andexcitability.Like many other types of ion channels, the activity of Kir channels transport K+ ions cross membranes
会议
Kir channelPIP2GatingHomology modelTargeted molecular dynamics
ASIC1a channel mediates neuronal necroptosis independent of its ion conducting function
Necrosis is an important form of cell demise during organ development and diseases.Traditionally, necrosis has been considered as an accidental, uncontrolled form of cell death.Increasing evidence now
会议
necroptosisnon-conducting function of ion channelASIC1a
Collection of Permeation Ions at the Mouth of the Pore Remove the Voltage Dependent Block of Kir2 Ch
Potassium inward rectifying (Kir) channels are a class of transmembrane proteins which play important roles in various physiological processes, controlling the resting membrane potential, regulating e
会议
Kir2.2 channelExtracellular Mg2+Molecular dynamicsHomology modelVoltage depe
Regulation of NMDA-induced neuronal excitability by TRPC6 channels
Overactivation of NMDA receptor is a key event in excitotoxicity that induces a sudden intracellular.Ca2+ elevation and finally leads to cell apoptosis and necrosis and inhibition of the Ca2+ overload
会议
TRPC6 channelsNMDACa2+excitotoxicitymembrane depolarization
Voltage Dependent Potassium Channel Remodeling in Murine Intestinal Smooth Muscle Hypertrophy Induce
Partial obstruction of the small intestine causes obvious hypertrophy of smooth muscle cells and motility disorder in the bowel proximate to the obstruction.To identify electric remodeling of hypertro
会议
Voltage dependent potassium channelpartial obstruction
Estrogen attenuates P2X3 receptor-mediated pain signal transduction via ERalpha and GPR30
Estrogen has been reported to affect pain perception, although the underlying mechanisms remain unclear.In this investigation, pain behavior testing, patch clamp recording and immunohistochemistry wer
会议
17(β)-estradiolP2X3 receptorpain
Tannic acid inhibits the excitability of small DRG neurons and the ionic mechanisms
Tannic acid is present in relatively high concentrations in red wines and green teas and has been proposed to be involved in multiple beneficial health effects.In this study, we revealed the efficacy
会议
Tannic acidpainDRGM-type K+currentsNa+currentCa2+-activated Cl-currents
Lipid binding is acquired for normal subcellular distribution and surface targeting of acid-sensing
Acid-sensing ion channel (ASIC) is a family of cation channels that are activated by extracellular pH reduction.Subunit l a (ASIC1a) is wildly expressed throughout the neural system and has been repor
会议
ASIC1a traffickingphospholipids
The effects of PIP2 on single channel kinetics of KCNQ Channels
Membrane lipids play a vital role in regulating the activities of ion channels and receptors, besides its inert supporting mission.The polarized membrane lipid components, especially phosphatidylinosi
会议
KCNQ channelsPIP2Single channel kinetics