【摘 要】
：
Abnormal DNA methylation is an important epigenetic regulator involving tumorigenesis.Deciphering cancer common and specific DNA methylation patterns is ess
【机 构】
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西安电子科技大学计算机学院,西安710071
【出 处】
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第七届全国生物信息学与系统生物学学术大会
论文部分内容阅读
Abnormal DNA methylation is an important epigenetic regulator involving tumorigenesis.Deciphering cancer common and specific DNA methylation patterns is essential for us to understand the mechanisms of tumor development.We investigate cancer common and specific DNA methylation patterns among 5480 DNA methylation profiles of 15 cancer types from TCGA.We first define differentially methylated CpG sites (DMCs) in each cancer and then identify 5450 hyper-and 4433 hypomethylated pan-cancer DMCs (PDMCs).Moreover,we identify six distinct motif clusters,which are enriched in hyper-or hypomethylated PDMCs and are associated with several well-known cancer hallmarks.We also observe that PDMCs relate to distinct transcriptional groups.Additionally,55 hypermethylated and 7 hypomethylated PDMCs are significantly associated with patient survival.Lastly,we find that cancer-specific DMCs are enriched in known cancer genes and cell-type-specific super-enhancers.In summary,this study provides a comprehensive investigation and reveals meaningful cancer common and specific DNA methylation patterns.
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