【摘 要】
：
Alkylation reaction utilizing alcohols as alkylating reagents through a borrow-hydrogen(BH)or hydrogen autotransfer(HA)strategy has emerged as a powerful tool to construct C-C bonds.1,2 During these t
【机 构】
：
College of Chemistry and Molecular Engineering,Zhengzhou University,No.100 of Science Road,Zhengzhou
【出 处】
：
中国化学会第十六届全国有机合成化学学术研讨会
论文部分内容阅读
Alkylation reaction utilizing alcohols as alkylating reagents through a borrow-hydrogen(BH)or hydrogen autotransfer(HA)strategy has emerged as a powerful tool to construct C-C bonds.1,2 During these transformations,water is generated as the only byproduct,which is more atom economical and environmentally benign.In our work,we have successfully prepared eight unsymmetrical NNN′ pincer Ru(Ⅱ)complexes with tunable steric and electronic effects on the imidazoline moiety.It was found that the electronic factor played an important role in determining the reaction efficiency in the α-alkylation of nitriles.Also,Ru(Ⅱ)complex 2h bearing a strong electron-withdrawing group exhibited the highest catalytic activity.The current strategy is featured with several characteristic,including low catalyst and base loading,short reaction time,and environmentally benign.
其他文献
The tetrahydrocarbazole architecture is a privileged heterocyclic ring system.It not only widely exists in various naturally occurring alkaloids and pharmacologically active compounds,but also is feat
Natural and synthetic congeners of carbazole comprise a large group of therapeutically useful agents in medicinal chemistry.Herein a series of novel isopropanol-bridged sulfonyl carbazoles as novel po
A series of Ofloxacin imidazole hybrids as potentially antimicrobial agents have been successfully synthesized via multistep reactions starting from commercial ethyl acetoacetate and triethylorthoform
Natural products play an important role for the development of most of the biologically active compounds due to the presence of enormous structure and chemical diversity which cannot be matched by any
氮氧螺杂环骨架广泛存在于天然产物的核心结构中，具有独特的生物活性，如钙通道抑制活性(LycoplanineA)，以及对多种肿瘤的抗增殖活性(青霉素A).Diels-Alder(DA)反应是构建六元环体系最重要和最基础的方式之一.目前为止，只有少数报道了对映体选择性反电子需求氧杂Diels-Alder反应，它们主要利用，α，β-不饱和羰基化合物作为双烯化合物与富电子烯烃进行环加成反应.1因此，研究其
A series of new potentially multi-targeting antimicrobial naphthalimide-derived fluconazole analogs were designed and conveniently synthesized from 4-bromonaphthalic anhydride.Their structures were ch
As an important class of N-heterocycles,quinazoline derivatives are prevalent in many nature products and synthetic drugs with wide therapeutic and pharmacological applications.1 Due to the importance
As a privileged N-heterocycle,imidazo[1,2-α]pyridines have exhibited various biological activities.1 With properly installation of amidomethyl,hydroxylmethyl,or other groups at C3 position followed by
Transition-metal-catalyzed C-H functionalization has been extensively investigated with great application in the syntheses of bioactive molecule and functional materials.1Meanwhile,catalytic C-C bond-
Copper plays an important role in many physiological activities,and its concentration above or below the normal levels will cause an adverse effect on the organism.1 Therefore,the design and synthesis