【摘 要】
：
1.Systemic chemotherapy is invariably associated with side effects,due to the fact that cytostatic drugs have an effect on all proliferating cells in the bo
【机 构】
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Department of Radio-Oncology Paracelsus Hospital Osnabrück Germany
【出 处】
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中国上海第七届国际新药发明科技年会
论文部分内容阅读
1.Systemic chemotherapy is invariably associated with side effects,due to the fact that cytostatic drugs have an effect on all proliferating cells in the body.In order to render chemotherapy more effective and to reduce side effects,various methods of drug targeting have been developed.Here the cytostatic drug is coupled to a carrier and thus transported on target to the tumour,where it becomes detached from the carrier and delivers its effect locally.The experiments presented here for magnetic drug targeting were conducted with ferrofluids.Ferrofluids are aqueous colloidal solutions made of magnetisable nanoparticles,comprising a Fe3O4 core with a coating,in this case made of dextran,which the cytostatic agent is coupled with.A magnetic field enables these nanoparticles to be passed through the body targeted to the tumour.
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