Understanding the Structure and Function of ZIP7: A Zinc Transporter Implicated in Modulating Glycae

来源 :2013第三届内分泌与代谢大会暨2013第二届糖尿病大会 | 被引量 : 0次 | 上传用户:CayleeDak_83
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  Type 2 diabetes is an increasingly prevalent metabolic disease characterised bya loss of glycaemic control.If left unmanaged further complications includechronic hyperglycaemiawhich is a major risk factor forhypertension and cardiovascular disease.This disease is commonly the result ofinsulin resistance in peripheral tissues such as skeletal muscle as well as relative insulin deficiency due to pancreaticβ-cell dysfunction.Zinc has been found to facilitate insulin signaling and aberrant zinc homeostasis has been linked to reduced insulin responsiveness and may therefore contribute to insulin resistance.
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