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The current treatment for metastatic gastric cancer is ineffective because of the poor prognosis and the development of resistance against chemotherapeutic drugs.Hence, new agents that are safe and effective are urgently needed.Gamma-tocotrienol (GT) is one such agent which is safe and multitargeted; and has been linked with suppression of survival, proliferation, invasion and angiogenesis of cancer.Whether GT can sensitize gastric cancer to capecitabine in vitro and in vivo was investigated.