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Objective: To investigate zinc finger protein 139 (ZNF139)expression and RUNX3 methylation in gastric cancer and their relationship with clinicopathological characteristics.Methods: Up to 55 cases of gastric fresh tumor specimens and paired tumor-adjacent tissues were collected.Data regarding clinicopathological characteristics were also recorded.ZNF139expressions were determined by RT-PCR, and RUNX3methylation was tested by methylation-specific PCR (MSP) assay.Results: ZNF139 expressions were stronger in tumors than in tumor-adjacent tissues.P was correlated with tumor size,differentiation, tumor invasion depth, and lymph node metastasis;P (54.55％) was higher than that in tumor-adjacent tissues (7.27％).P was correlated with differentiation, tumor invasion depth, and lymph node metastasis (all P significant relationships were found between ZNF 139 mRNA and RUNX3 methylation).